Collaborative Proposal: Genomics across the speciation continuum in Heliconius butterflies

合作提案：Heliconius 蝴蝶物种形成连续体的基因组学

• 批准号: 1257839
• 负责人: Brian Counterman
• 金额: $ 75万
• 依托单位: Mississippi State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1257839&HistoricalAwards=false
• 关键词: Collaborative; Proposal; Genomics; across; speciation

Discovering how genomes change as populations diverge is essential to understanding how species arise. When populations begin to diverge most of their genomes will often remain very similar, except for those regions that are responsible for adaptive differences between the populations. As populations become increasingly isolated from each other during the speciation process, their genomes also become increasingly different from each other, particularly at regions that underlie adaptive or reproductive differences between the populations. Yet researchers know little about how, why, and where differences actually accumulate across the genome. This collaborative project will leverage recent advances in genome sequencing technology and the frequent hybridization between divergent races and species of Heliconius butterflies to assemble a moving picture of how genomes change over time and test specific hypotheses about what causes genomes to change in certain ways.This project will provide one of the most comprehensive examinations of the genomic consequences of speciation. With this knowledge, researchers will begin to understand the type of genetic changes that lead to the origin of new species. The use of cutting edge genome sequencing technology, along with the expertise of the collaborative research team, will lead to the development of new analytical tools and methods that will be broadly useful to scientific community. Training and outreach workshops will provide unique opportunities for students, teachers, and researchers to gain hands-on experience in how genomics can be used to study the amazing diversity found in nature.

发现基因组随着人群的分歧而变化对于了解物种的出现至关重要。当种群开始分歧时，大多数基因组通常会非常相似，除了那些负责人群之间适应性差异的地区。随着种群越来越多地彼此隔离，它们的基因组也变得越来越不同，尤其是在人群之间适应性或生殖差异的区域。然而，研究人员对整个基因组的差异实际积累了如何，为什么和何处了解。这个合作项目将利用基因组测序技术的最新进展以及发散种族和Heliconius蝴蝶种之间的频繁杂交来组装基因组如何随着时间而变化并测试导致基因组发生变化的特定假设的动态图，这些项目将以某些方式变化。这些项目将提供基因组概念性影响的最全面检查。有了这些知识，研究人员将开始理解导致新物种起源的遗传变化的类型。尖端基因组测序技术的使用以及协作研究团队的专业知识将导致开发新的分析工具和方法，这些工具和方法将对科学界广泛有用。培训和推广讲习班将为学生，老师和研究人员提供独特的机会，以获得如何使用基因组学来研究自然界中发现的惊人多样性的动手经验。