SusChEM: CAREER: Ketone Alkylation Using Simple Olefins: A Sustainable Chemistry Approach

SusChEM：职业：使用简单烯烃的酮烷基化：一种可持续的化学方法

• 批准号: 1254935
• 负责人: Guangbin Dong
• 金额: $ 65万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1254935&HistoricalAwards=false
• 关键词: SusChEM; CAREER; Ketone; Alkylation; Using

The Chemical Catalysis Program of the NSF Division of Chemistry supports the research efforts of Professor Guangbin Dong of the University of Texas at Austin to explore new catalytic reactions for the formation of carbon-carbon (C-C) bonds through ketone alkylation reactions. Professor Dong's group uses a transition metal catalyzed enamine-mediated carbon-hydrogen (C-H) functionalization strategy to transform simple, unactivated olefins. This new reaction offers a number of advantages over the classical ketone-akylation methods, including the substitution of expensive or toxic halide reactants with more environmentally benign and less costly olefins, the use of neutral catalytic conditions rather than stoichiometric amounts of strong bases, and the development of a by-product free process. Professor Dong is actively engaged in the Research Experiences for Undergraduates (REU) IMPACT Program for undergraduate mentoring, the Welch Summer Scholar Program for high school student training, and the "Shadow a Scientist" program for the early education of middle school and home-schooled students. Professor Dong is also collaborating with UT Austin's Student Veteran Services to create research opportunities for veterans and pre-veterans by providing training in Green Chemistry. As one of the oldest and most-utilized carbon-carbon bond formation reactions, ketone alkylation, has not been an economical or environmentally-friendly process. This CAREER project utilizes transition metal-based catalytic processes to avoid the need for corrosive bases and/or toxic and expensive reagents. The improved reactions are expected to have impact in the preparation of pharmaceutical agents, polymers, fine chemicals, and flavoring reactions. Professor Dong stresses the environment and the use of sustainable processes in his work with middle and high school students as well as in the home-school environment. These activities involved participants from diverse age groups and backgrounds. His outreach and education efforts also involve creating research opportunities for veterans and students readying for deployment so that they can be employed by the chemical industry after their military service.

NSF化学司的化学催化计划支持德克萨斯大学奥斯汀分校的广鸟教授的研究工作，以探索通过酮烷基化反应形成碳碳（C-C）键的新催化反应。 Dong教授的小组使用过渡金属催化的烯胺介导的碳 - 氢（C-H）功能化策略来改变简单的，未激活的烯烃。 这一新反应比经典的酮 - 甲基化方法具有许多优势，包括替代昂贵的或有毒的卤化物反应物，其环境良性更高且昂贵的烯烃，使用中性催化条件，而不是使用石学计量的强质量强碱，以及源于副产品免费过程的发展。 Dong教授正在积极从事大学生的研究经验（REU）本科指导的影响计划，高中生培训的韦尔奇夏季学者计划以及“ Shadow a A Scientist”课程，用于早期的中学和家庭教育学生。 Dong教授还与UT Austin的学生退伍军人服务合作，通过提供绿色化学培训为退伍军人和退伍军人创造研究机会。作为最古老，最利用的碳碳键形成反应之一，酮烷基化不是经济或环保的过程。 该职业项目利用基于过渡金属的催化过程来避免需要腐蚀性基础和/或有毒和昂贵的试剂。 预计改进的反应将对制备药物，聚合物，细化学物质和调味反应产生影响。 Dong教授强调了与中学生以及家庭学校环境中的环境和可持续过程的使用。 这些活动涉及来自不同年龄段和背景的参与者。 他的宣传和教育工作还涉及为准备部署的退伍军人和学生创造研究机会，以便在服兵役后可以被化学工业雇用。