Evolution of Metabolic Innovation: Aerobic Fermentation in Yeasts as an Example

代谢创新的演变：以酵母菌的有氧发酵为例

• 批准号: 1243588
• 负责人: Zhenglong Gu
• 金额: $ 52.84万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-15 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1243588&HistoricalAwards=false
• 关键词: Evolution; Metabolic; Innovation; Aerobic; Fermentation

Intellectual Merits: One of the central issues in the evolutionary field is to understand the impact of duplicate genes on evolution. The proposed research will contribute to this understanding by demonstrating how gene duplication contributes to metabolic innovation and specifically to aerobic fermentation in yeast. The research builds on a kinetic modeling framework to investigate how gene duplication contributed to the evolution of novel metabolic functions. One aspect of the research will explore also the evolutionary connection of gene duplication and novel gene regulatory mechanisms and how these contribute to cellular metabolic innovation. Broader Impacts: This research will have important broader impacts. It will train students, including graduate, undergraduate and high school students. The PI is involved in multiple activities to include minority students with the hope to encourage and support a diverse next generation of evolutionary scientists. Aerobic fermentation in yeast has broader implication for agricultural and industrial industries. The link between nutrition and evolution itself represents an attractive case study for the edcuation of the public on the subject of evolution.

智力优点：进化领域的主要问题之一是了解重复基因对进化的影响。拟议的研究将通过证明基因复制如何有助于代谢创新，特别是酵母中有氧发酵的方法来促进这种理解。该研究基于动力学建模框架，以研究基因复制如何促进新代谢功能的演变。该研究的一个方面还将探索基因复制和新型基因调节机制的进化联系，以及它们如何促进细胞代谢创新。更广泛的影响：这项研究将产生重要的广泛影响。它将培训学生，包括毕业生，本科生和高中生。 PI参与了多种活动，包括少数族裔学生，希望鼓励和支持多样化的下一代进化科学家。酵母中的有氧发酵对农业和工业产业具有更大的影响。营养与进化本身之间的联系代表了一个有吸引力的案例研究，以对公众进行进化论。