EFRI-PSBR: Cyanobacterial Biorefineries

EFRI-PSBR：蓝藻生物精炼厂

基本信息

批准号：
1240268
负责人：
Brian Pfleger
金额：
$ 200万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2018-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1240268&HistoricalAwards=false
关键词：
EFRI PSBR Cyanobacterial Biorefineries

项目摘要

Technical Impacts-A useful long term vision of the chemical industry integrates the use of modern biotechnology and chemical catalysis to engineer systems where everyday fuels and chemicals are produced from renewable resources. The vision of this award, made to Professors Brian F. Pfleger, Christos Maravelias, Katherine D. McMahon, Thatcher W. Root and Andrew Greenberg of the University of Wisconsin-Madison is to develop and evaluate a biorefinery strategy using cyanobacteria to produce compounds that support a chemical industry based on photosynthesis. It will demonstrate methods for producing high-value commodity chemicals from CO2 and sunlight that will replace current petrochemical-based processes. Key fundamental questions that will guide the establishment of such a sustainable chemical economy based on photosynthetic cyanobacteria include: 1) What chemicals, i.e. final products or intermediates of value, should be made by living systems to optimize a chemical industry based on photosynthesis? 2) At what rate and fraction of theoretical yield can cyanobacteria produce target compounds? 3) What process parameters are critical to effectively scale up photosynthetic bioreactors from the laboratory to industrial size? Is there a limit to the feasible size of a photosynthetic biorefinery? 4) Can a photosynthetic biorefinery be integrated with waste remediation (e.g. municipal wastewater treatment) to simultaneously meet sustainability and environmental objectives? This award details a number of key features in the fundamental science and technology supporting their photosynthetic biorefinery vision, and is made through the Emerging Frontiers in Research and Innovation Program at NSF. Broader Impacts- In the long term the proposed work will contribute to restructuring the chemical industry away from fossil fuels and towards renewable carbon sources. In addition establishing photosynthetic biorefineries is a route for achieving energy security and maintaining national defense. Deployment of successful, commercial photosynthetic biorefineries could generate a sustainable source of fuels and chemicals without altering current agricultural practices. Impact on education and outreach has many individual strategies proposed by the PIs, including a)Integrating technoeconomic analysis and LCA into CBE process design and lab courses; b)Providing independent study and research experiences for undergraduates in the university labs; c) Mentoring an interdisciplinary undergraduate synthetic biology research team (iGEM); d) Providing summer research experiences for high-school students and teachers; and e) Recruiting students from underrepresented groups through successful, existing UW-Madison programs.

技术影响 - 化学工业的有用的长期视野将现代生物技术和化学催化的使用整合到工程师系统中，在这些系统中，日常燃料和化学物质是由可再生资源产生的。该奖项的愿景是向威斯康星大学麦迪逊分校的教授布莱恩·F·普莱格（Brian F.它将展示从CO2和阳光中生产高价值商品化学物质的方法，这些化学物质将取代当前基于石化的过程。基于光合作用的蓝细菌的指导建立这种可持续化学经济的关键基本问题包括：1）生活系统应该制造哪些化学药品，即最终产品或价值中间人，以根据光合作用来优化化学工业？ 2）以理论产量的速率和分数，蓝细菌可以产生目标化合物？ 3）哪些过程参数对于从实验室到工业规模有效扩展光合生物反应器至关重要？光合生物填充物的可行尺寸是否有限制？ 4）是否可以将光合生物融资与废物修复（例如市政废水处理）集成在一起，以同时满足可持续性和环境目标？该奖项详细介绍了支持其光合生物融资愿景的基本科学和技术的许多关键功能，并通过NSF的研究和创新计划的新兴前沿制造。更广泛的影响 - 从长远来看，拟议的工作将有助于将化学工业从化石燃料和可再生碳来源重组。此外，建立光合生物精制是实现能源安全和维持国防的途径。开展成功的商业光合生物精制的部署可以产生可持续的燃料和化学品来源，而不会改变当前的农业实践。对教育和外展的影响有PI提出的许多个人策略，包括a）将技术经济分析和LCA整合到CBE流程设计和实验室课程中； b）在大学实验室为大学生提供独立的研究和研究经验； c）指导跨学科的本科生合成生物学研究团队（IGEM）； d）为高中生和老师提供夏季研究经验； e）通过成功现有的UW麦迪逊计划，从代表性不足的群体中招募学生。