Synthesis, Self-assembly and Morphology Transitions in Linear and Star Polypeptide-based Block Copolymers

线性和星形多肽嵌段共聚物的合成、自组装和形态转变

• 批准号: 1213840
• 负责人: Daniel Savin
• 金额: $ 36万
• 依托单位: University of Southern Mississippi
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213840&HistoricalAwards=false
• 关键词: Synthesis; Self; assembly; Morphology; Transitions

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Daniel Savin of the University of Southern Mississippi will synthesize study the interplay between the chemical composition and environment of coil-rod-coil triblock copolymers and their interchange between vesicle, disk and nanotube assemblies. The approach is to synthesize symmetric, linear triblock copolymers and three-arm star copolymers; to explore their solution self-assembly as a function of composition; to use pH and temperature to induce changes in the solution morphology of the polypeptide-based block copolymer assemblies; and to determine what factors of helix assembly, pH and temperature responsiveness dictate the interfacial curvature for block copolymer assembly into vesicles, disks or nanotubes. The broader impacts involve training graduate and undergraduate students to gain a comprehensive understanding of polymer chemistry, characterization and morphology from a fundamental and applied standpoint as well as outreach activities including the Kids' Science Challenge, web-based educational modules through NBC Learn, and the ACS Science Coaches program.Polymers are long chain organic molecules and are found in many facets of everyday life, including food packaging, structural materials for automotive and aerospace transportation, and lightweight electronic devices. Block copolymers are long chain organic molecules in which two or more chemically distinct polymer chains are attached by their ends. When a block copolymer is placed in a liquid that preferentially dissolves one of the segments, the individual chains assemble into a range of structures with nanometer scale dimensions. This work aims to enhance our fundamental understanding of the chemistry behind the block copolymer assembly process. The results of these studies could have important long term impacts on many applications including drug delivery, biosensing, pharmaceutical processing, and nanotechnology.

在这个由化学部高分子、超分子和纳米化学项目资助的项目中，南密西西比大学的 Daniel Savin 将综合研究线圈-杆-线圈三嵌段共聚物的化学成分和环境之间的相互作用以及它们在囊泡之间的互换，盘和纳米管组件。 该方法是合成对称的线性三嵌段共聚物和三臂星形共聚物；探索他们的解决方案自组装作为组成的函数；使用pH和温度来诱导基于多肽的嵌段共聚物组装体的溶液形态的变化；并确定螺旋组装、pH 和温度响应性的哪些因素决定了嵌段共聚物组装成囊泡、圆盘或纳米管的界面曲率。 更广泛的影响包括培训研究生和本科生从基础和应用的角度全面了解高分子化学、表征和形态，以及外展活动，包括儿童科学挑战赛、通过 NBC Learn 进行的基于网络的教育模块以及ACS 科学教练计划。聚合物是长链有机分子，存在于日常生活的许多方面，包括食品包装、汽车和航空航天运输的结构材料以及轻型电子设备。 嵌段共聚物是长链有机分子，其中两个或多个化学上不同的聚合物链通过其末端连接。当将嵌段共聚物置于优先溶解其中一个链段的液体中时，各个链会组装成一系列具有纳米级尺寸的结构。 这项工作旨在增强我们对嵌段共聚物组装过程背后的化学的基本理解。 这些研究的结果可能对许多应用产生重要的长期影响，包括药物输送、生物传感、药物加工和纳米技术。