Neural Mechanisms of Trust and Dyadic Interaction in BPD

BPD 中信任和二元相互作用的神经机制

• 批准号: 206468010
• 负责人: Professor Dr. Peter Kirsch
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/206468010?language=en
• 关键词: Neural; Mechanisms; Trust; Dyadic; Interaction

Aim of IP3 is the identification of abnormal interbrain activity and connectivity during impaired interpersonal processes in BPD using hyperscanning which permits the measurement of brain activity simultaneously in two interacting people. During the first funding period, we established a new, generalizable, robust and hypothesis-free analysis method for hyperscanning data while collecting data from both healthy controls and patients. A Joint Attention (JA) task was chosen for the initial investigation, since it represents a fundamental, simple and developmentally early form of specifically human social interaction. Data from two healthy samples showed that during JA, coupling between brain systems emerges that is unique to truly interacting subjects, and temporally and spatially highly specific, centering on the right temporo-parietal junction (rTPJ). In our first study, currently involving 22 BPD pairs, formed from patient interacting with one control participant, we found that neural coupling parameters during JA were affected by illness status. No significant coupling in dyads involving a BPD subject was observable during JA, providing the first observation of a disruption in this early processing stage of social information in BPD. In addition, initial analysis of the 2nd study, a multi-round trust game showed a comparable reduction in rTPJ coupling when BPD patients were involved in the interaction. This result might indicate that we identified a fundamental neural mechanism of social interaction, interbrain coupling, which is already impaired in BPD patients in very basal kinds of social interaction but affects social functioning on all levels of complexity. Disturbed JA has been extensively investigated in autism spectrum disorders (ASD). Recently a subgroup BPD patients has been described that also meets the criteria for ASD. It would therefore be interesting to test whether the reduced coupling during JA can also be observed in ASD patients and whether we identified a shared mechanism affecting social functioning in BPS and ASD. Therefore, we now aim to further characterize and explore neural coupling during JA and its disturbance in BPD patients. We will first investigate associations between disturbed neural coupling during JA, clinical ASD features and social functions in BPD and ASD patients. Second, we will investigate the genetic underpinnings of impaired coupling during JA specifically emphasizing the role of the oxytocin receptor gene (OXTR). Third, we will investigate the change of the signature over the course of the disorder looking on a larger sample of remitted BPD patients and fourth, we will investigate JA within borderline dyads in more details. In addition, to directly relate rTPJ function to social interaction, we will conduct a pilot study in BPD and ASD patients, where we use transcranial magnetic stimulation (TMS) to excite the region and test resulting effects on neural coupling parameters during social interaction.

IP3的目的是使用Hyperscanning在BPD中识别脑间活动和连通性异常，这允许在两个相互作用的人中同时测量大脑活动。在第一个资金期间，我们建立了一种新的，可推广的，可靠的和假设的分析方法，用于超级扫描数据，同时从健康对照和患者那里收集数据。选择了共同关注（JA）任务进行初步研究，因为它代表了人类社会互动的基本，简单和发展的早期形式。来自两个健康样本的数据表明，在JA期间，出现了大脑系统之间的耦合，这是真正相互作用的受试者以及时间和空间高度特异性的独有的，以右颞顶结（RTPJ）为中心。在我们目前涉及22个BPD对的第一项研究中，由患者与一名对照参与者互动形成，我们发现JA期间的神经偶联参数受疾病状况的影响。在JA期间，无法观察到涉及BPD受试者的二元组的显着耦合，这是BPD社会信息的早期处理阶段的首次观察。此外，对第二项研究的初步分析，当BPD患者参与相互作用时，多轮信任游戏显示了RTPJ耦合的降低。该结果可能表明，我们确定了社会互动，脑间耦合的基本神经机制，在BPD患者中已经受到了非常基础的社会互动的损害，但会影响各个复杂性的社会功能。干扰的JA已在自闭症谱系障碍（ASD）中进行了广泛的研究。最近，已经描述了一个亚组BPD患者，该患者也符合ASD的标准。因此，测试在ASD患者中还可以观察到JA期间耦合减少以及我们是否确定了影响BPS和ASD中社会功能的共同机制，这将很有趣。因此，我们现在的目标是进一步表征和探索JA期间的神经偶联及其在BPD患者中的干扰。我们将首先研究JA期间神经偶联，BPD和ASD患者的临床ASD特征和社交功能之间的关联。其次，我们将研究JA期间耦合受损偶联的遗传基础，该基因强调了催产素受体基因（OXTR）的作用。第三，我们将研究疾病过程中签名的变化，以查看较大的寄回BPD患者样本，第四名，我们将在边界二元组中调查JA，以提供更多细节。此外，为了将RTPJ功能与社交相互作用直接相关，我们将对BPD和ASD患者进行试点研究，在那里我们使用经颅磁刺激（TMS）激发该区域并在社交相互作用过程中对神经偶联参数产生影响。

项目成果

State-Dependent Cross-Brain Information Flow in Borderline Personality Disorder

• DOI: 10.1001/jamapsychiatry.2017.1682
• 发表时间: 2017-09-01
• 期刊: JAMA PSYCHIATRY
• 影响因子: 25.8
• 作者: Bilek, Edda;Stoessel, Gabriela;Meyer-Lindenberg, Andreas
• 通讯作者: Meyer-Lindenberg, Andreas

Information flow between interacting human brains: Identification, validation, and relationship to social expertise

• DOI: 10.1073/pnas.1421831112
• 发表时间: 2015-04-21
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Bilek, Edda;Ruf, Matthias;Meyer-Lindenberg, Andreas
• 通讯作者: Meyer-Lindenberg, Andreas