Experimental studies on rumination and mindfulness: A multilevel approach using fMRI and ambulatory assessment in clinical and nonclinical samples

沉思和正念的实验研究：在临床和非临床样本中使用功能磁共振成像和动态评估的多层次方法

• 批准号: 166393969
• 负责人: Professor Dr. Peter Kirsch
• 金额: --
• 依托单位: Abteilung Klinische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/166393969?language=en
• 关键词: Experimental; studies; rumination; mindfulness; multilevel

During the first funding period (2010-2013), the project investigated functional connectivity and neural correlates of induced attention foci (rumination, mindfulness) using fMRI, and effects of spontaneous and induced attention foci on emotional, cognitive and endocrinological processes in daily life in remitted depressed patients and healthy controls. In this context, we examine the relationship between results of both measurement levels (fMRI, ambulatory assessment, AA) and their predictive value for the course of symptoms. By integrating both research approaches, our project pursues an as yet completely new approach in the area of rumination and mindfulness research. In the second funding period (2013-2016) we aim at investigating AA- and fMRI-based predictors identified during the first funding period with regard to their potential to predict the long-term symptom course and risk of relapse/recurrence in patients, as well as at investigating intervention effects of a specific mindfulness-based attention training on neural and everyday parameters in a new sample of patients.Substudy 1 intends to conduct a concluding three-year-follow-up of the remitted depressed patients (n=60) investigated in study period 1. This allows an examination of long-term predictive effects of depression-related alterations in AA- and fMRI-based variables for the longterm course of symptoms in this already extensively characterized sample. Amongst others, we assume that increased daily rumination, worse mood states and a decreased cortisol response towards subjective experiences in daily life will predict a worse course of symptoms and an increased risk of relapse/recurrence. We also expect that the increased functional connectivity identified within the Default Mode Network (DMN) in patients during negative mood and rumination induction will predict a disadvantageous course of symptoms over the three-year period. Finally, we expect that the relationship between degree of functional connectivity at baseline and the course of symptoms will be mediated by the degree of daily rumination at baseline.Substudy 2 aims to investigate the short-term effects of a four-week mindfulness-based attention training (n=35) compared to a time-matched active control condition (progressive muscle relaxation, n=35) in a randomised experimental intervention study on changes in functional connectivity of the DMN as well as rumination, emotional processes, and cortisol activity in daily life in a new sample of remitted recurrent depressed patients. In particular, we expect that the mindfulness training will lead to a stronger decrease in functional connectivity in the DMN, to a more substantial reduction in daily rumination, and to larger increases in autobiographical memory specificity and habitual mindfulness. Finally, we expect that improvements in daily rumination will mediate the effect of the intervention on functional connectivity in the DMN.

在第一个资金期（2010-2013）中，该项目研究了使用fMRI的功能连通性和诱导的注意力灶（反省，正念）的神经相关性，以及自发性和诱导的注意力重点对恢复抑郁症患者和健康对照的日常生活中情绪，认知和内分泌过程的影响。在这种情况下，我们检查了测量水平（fMRI，门诊评估，AA）的结果与症状过程中的预测价值之间的关系。通过整合两种研究方法，我们的项目在反思和正念研究领域采用了一种全新的方法。在第二个资金期（2013-2016）中，我们旨在调查第一个资助期间确定的基于AA和FMRI的预测因素，这些预测可能预测患者的长期症状课程和复发/复发的风险，以及调查针对患者的新样本的特定注意事项的干预效果，以调查患者的特定注意事项。在研究期1中研究的抑郁症患者（n = 60）。这允许检查基于AA和FMRI的变量与抑郁症相关变化的长期预测作用，以在此已经广泛表征的样本中，对长期症状的长期症状进行了研究。除其他外，我们假设每天的反省，情绪状况较差，皮质醇对日常生活中主观经历的反应减少将预测症状的过程和复发/复发风险增加。我们还期望在负面情绪和反省诱导期间，患者在默认模式网络（DMN）中确定的功能连通性的提高将预测三年内症状的劣势。 Finally, we expect that the relationship between degree of functional connectivity at baseline and the course of symptoms will be mediated by the degree of daily rumination at baseline.Substudy 2 aims to investigate the short-term effects of a four-week mindfulness-based attention training (n=35) compared to a time-matched active control condition (progressive muscle relaxation, n=35) in a randomised experimental intervention study on changes in functional connectivity of the DMN as well as新的复发性抑郁症患者样本中的日常生活中的反省，情绪过程和皮质醇活性。特别是，我们期望正念训练将导致DMN功能连通性的更大降低，每天反省的更大减少，并增加自传记忆的特异性和习惯性正念。最后，我们预计每日反省的改善将调解干预对DMN功能连通性的影响。

项目成果

Effects of mood and rumination on cortisol levels in daily life: An ambulatory assessment study in remitted depressed patients and healthy controls

• DOI: 10.1016/j.psyneuen.2013.04.014
• 发表时间: 2013-10-01
• 期刊: PSYCHONEUROENDOCRINOLOGY
• 影响因子: 3.7
• 作者: Huffziger, Silke;Ebner-Priemer, Ulrich;Kuehner, Christine
• 通讯作者: Kuehner, Christine

Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients

• DOI: 10.1371/journal.pone.0178759
• 发表时间: 2017-06-02
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Timm, Christina;Ubl, Bettina;Kuehner, Christine
• 通讯作者: Kuehner, Christine

Induced rumination in everyday life: Advancing research approaches to study rumination

• DOI: 10.1016/j.paid.2012.06.009
• 发表时间: 2012-10-01
• 期刊: PERSONALITY AND INDIVIDUAL DIFFERENCES
• 影响因子: 4.3
• 作者: Huffziger, Silke;Ebner-Priemer, Ulrich;Kuehner, Christine
• 通讯作者: Kuehner, Christine

Examining the Relation Between Mood and Rumination in Remitted Depressed Individuals

检查抑郁症缓解者的情绪与沉思之间的关系

• DOI: 10.1177/2167702615578129
• 发表时间: 2015
• 期刊: Clinical Psychological Science
• 影响因子: 4.8
• 作者: Koster EHW;Fang L;Marchetti I;Ebner-Priemer U;Kirsch P;Huffziger S;Kuehner C
• 通讯作者: Kuehner C

Mindfulness-Based Attention Training Improves Cognitive and Affective Processes in Daily Life in Remitted Patients with Recurrent Depression: A Randomized Controlled Trial

基于正念的注意力训练可改善复发性抑郁症缓解患者日常生活中的认知和情感过程：一项随机对照试验

• DOI: 10.1159/000488862
• 发表时间: 2018
• 期刊: Psychotherapy and Psychosomatics
• 影响因子: 22.8
• 作者: Timm C;Rachota-Ubl B;Beddig T;Zamoscik V;Ebner-Priemer U;Reinhard I;Kirsch P;Kuehner C
• 通讯作者: Kuehner C