Experimental studies on rumination and mindfulness: A multilevel approach using fMRI and ambulatory assessment in clinical and nonclinical samples

沉思和正念的实验研究：在临床和非临床样本中使用功能磁共振成像和动态评估的多层次方法

• 批准号: 166393969
• 负责人: Professor Dr. Peter Kirsch
• 金额: --
• 依托单位: Abteilung Klinische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/166393969?language=en
• 关键词: Experimental; studies; rumination; mindfulness; multilevel

During the first funding period (2010-2013), the project investigated functional connectivity and neural correlates of induced attention foci (rumination, mindfulness) using fMRI, and effects of spontaneous and induced attention foci on emotional, cognitive and endocrinological processes in daily life in remitted depressed patients and healthy controls. In this context, we examine the relationship between results of both measurement levels (fMRI, ambulatory assessment, AA) and their predictive value for the course of symptoms. By integrating both research approaches, our project pursues an as yet completely new approach in the area of rumination and mindfulness research. In the second funding period (2013-2016) we aim at investigating AA- and fMRI-based predictors identified during the first funding period with regard to their potential to predict the long-term symptom course and risk of relapse/recurrence in patients, as well as at investigating intervention effects of a specific mindfulness-based attention training on neural and everyday parameters in a new sample of patients.Substudy 1 intends to conduct a concluding three-year-follow-up of the remitted depressed patients (n=60) investigated in study period 1. This allows an examination of long-term predictive effects of depression-related alterations in AA- and fMRI-based variables for the longterm course of symptoms in this already extensively characterized sample. Amongst others, we assume that increased daily rumination, worse mood states and a decreased cortisol response towards subjective experiences in daily life will predict a worse course of symptoms and an increased risk of relapse/recurrence. We also expect that the increased functional connectivity identified within the Default Mode Network (DMN) in patients during negative mood and rumination induction will predict a disadvantageous course of symptoms over the three-year period. Finally, we expect that the relationship between degree of functional connectivity at baseline and the course of symptoms will be mediated by the degree of daily rumination at baseline.Substudy 2 aims to investigate the short-term effects of a four-week mindfulness-based attention training (n=35) compared to a time-matched active control condition (progressive muscle relaxation, n=35) in a randomised experimental intervention study on changes in functional connectivity of the DMN as well as rumination, emotional processes, and cortisol activity in daily life in a new sample of remitted recurrent depressed patients. In particular, we expect that the mindfulness training will lead to a stronger decrease in functional connectivity in the DMN, to a more substantial reduction in daily rumination, and to larger increases in autobiographical memory specificity and habitual mindfulness. Finally, we expect that improvements in daily rumination will mediate the effect of the intervention on functional connectivity in the DMN.

在第一个资助期间（2010-2013年），该项目利用功能磁共振成像研究了诱发注意焦点（沉思、正念）的功能连接和神经相关性，以及自发和诱发注意焦点对日常生活中情绪、认知和内分泌过程的影响。抑郁症患者和健康对照组的病情得到缓解。在这种情况下，我们研究了两种测量水平（fMRI、动态评估、AA）的结果与其对症状过程的预测价值之间的关系。通过整合这两种研究方法，我们的项目在沉思和正念研究领域追求一种全新的方法。在第二个资助期（2013-2016），我们的目标是调查第一个资助期确定的基于 AA 和 fMRI 的预测因子，了解它们预测患者长期症状过程和复发/复发风险的潜力，如以及调查特定的基于正念的注意力训练对新患者样本的神经和日常参数的干预效果。子研究 1 打算对缓解的抑郁症患者进行三年的总结性随访(n=60) 在研究期 1 中进行了调查。这使得可以在这个已经广泛表征的样本中检查基于 AA 和 fMRI 的变量的抑郁相关变化对症状长期进程的长期预测效果。除其他外，我们认为每日反省的增加、情绪状态的恶化以及对日常生活中主观体验的皮质醇反应的降低将预示着症状的恶化和复发/复发的风险的增加。我们还预计，在消极情绪和反刍诱导期间，患者默认模式网络（DMN）中发现的功能连接增加将预测三年期间的不利症状过程。最后，我们预计基线时的功能连接程度与症状进程之间的关系将由基线时的每日沉思程度来调节。子研究 2 旨在调查为期 4 周的基于正念的注意力的短期效果在一项随机实验干预研究中，将训练（n=35）与时间匹配的主动控制条件（渐进性肌肉放松，n=35）进行比较，研究DMN功能连接的变化以及沉思、情绪过程和皮质醇活动在一组新的复发性抑郁症缓解患者样本的日常生活中。特别是，我们预计正念训练将导致 DMN 中功能连接的更强烈下降，日常沉思的大幅减少，以及自传体记忆特异性和习惯性正念的更大增加。最后，我们预计日常沉思的改善将调节干预对 DMN 功能连接的影响。

项目成果

Effects of mood and rumination on cortisol levels in daily life: An ambulatory assessment study in remitted depressed patients and healthy controls

• DOI: 10.1016/j.psyneuen.2013.04.014
• 发表时间: 2013-10-01
• 期刊: PSYCHONEUROENDOCRINOLOGY
• 影响因子: 3.7
• 作者: Huffziger, Silke;Ebner-Priemer, Ulrich;Kuehner, Christine
• 通讯作者: Kuehner, Christine

Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients

• DOI: 10.1371/journal.pone.0178759
• 发表时间: 2017-06-02
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Timm, Christina;Ubl, Bettina;Kuehner, Christine
• 通讯作者: Kuehner, Christine

Examining the Relation Between Mood and Rumination in Remitted Depressed Individuals

检查抑郁症缓解者的情绪与沉思之间的关系

• DOI: 10.1177/2167702615578129
• 发表时间: 2015
• 期刊: Clinical Psychological Science
• 影响因子: 4.8
• 作者: Koster EHW;Fang L;Marchetti I;Ebner-Priemer U;Kirsch P;Huffziger S;Kuehner C
• 通讯作者: Kuehner C

Mindfulness-Based Attention Training Improves Cognitive and Affective Processes in Daily Life in Remitted Patients with Recurrent Depression: A Randomized Controlled Trial

基于正念的注意力训练可改善复发性抑郁症缓解患者日常生活中的认知和情感过程：一项随机对照试验

• DOI: 10.1159/000488862
• 发表时间: 2018
• 期刊: Psychotherapy and Psychosomatics
• 影响因子: 22.8
• 作者: Timm C;Rachota-Ubl B;Beddig T;Zamoscik V;Ebner-Priemer U;Reinhard I;Kirsch P;Kuehner C
• 通讯作者: Kuehner C

Induced rumination in everyday life: Advancing research approaches to study rumination

• DOI: 10.1016/j.paid.2012.06.009
• 发表时间: 2012-10-01
• 期刊: PERSONALITY AND INDIVIDUAL DIFFERENCES
• 影响因子: 4.3
• 作者: Huffziger, Silke;Ebner-Priemer, Ulrich;Kuehner, Christine
• 通讯作者: Kuehner, Christine