Genetic Instability at a Complex Gene Cluster in Arabidopsis

拟南芥复杂基因簇的遗传不稳定性

• 批准号: 1158297
• 负责人: Eric Richards
• 金额: $ 61.44万
• 依托单位: Boyce Thompson Institute Plant Research
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1158297&HistoricalAwards=false
• 关键词: Genetic; Instability; Complex; Gene; Cluster

Intellectual Merit:Flowering plants contain clusters of repeated genes, many of which are involved in recognition of pathogens. The structures of these genes are often highly variable and a combination of forces drives the diversification among repeated pathogen recognition genes. This project investigates a unique situation in the model flowering plant, Arabidopsis thaliana (mouse-ear cress), where the divergence between duplicated copies of a pathogen recognition gene called SNC1 is extremely rapid. The project focuses on this particular model to define the molecular mechanisms responsible for the frequent birth-and-death of pathogen resistance genes in plants.Broader Impacts:The project contains three different elements that broaden its impact. First, the research addresses fundamental questions regarding the ways that genetic change and rapid evolutionary processes occur. The results of the research will also provide insight into the forces that diversify a plant's arsenal of genes devoted to protection against agricultural pests. The second broader impact of the project will be the training and mentoring of scientists at the postdoctoral, graduate and undergraduate levels. Finally, the project directly engages high school students in the central New York region in an authentic collaborative research project, connecting these students, as well as their teachers, with scientists at the Boyce Thompson Institute.

智力优点：开花植物包含重复基因的簇，其中许多涉及病原体的识别。 这些基因的结构通常是高度可变的，并且力的组合驱动了重复的病原体识别基因之间的多样化。 该项目调查了模型开花植物拟南芥（Mouse-Aeal Cress）中的独特情况，其中称为SNC1的病原体识别基因的重复副本之间的差异非常快。 该项目的重点是该特定模型，以定义负责植物中病原体耐药基因出生和死亡的分子机制。BOADER的影响：该项目包含三个不同的元素来扩大其影响。 首先，研究解决了有关遗传变化和快速进化过程的方式的基本问题。 该研究的结果还将提供对植物库多样化的力量的洞察力，这些基因武器库用于保护农业害虫。 该项目的第二个更广泛的影响是在博士后，研究生和本科阶段对科学家的培训和指导。 最后，该项目直接与纽约中部地区的高中学生与一个真实的合作研究项目与博伊斯·汤普森学院的科学家联系起来，将这些学生及其老师与他们的老师联系起来。