Catalytic Regioselective Functionalization of Alkane and Arenes

烷烃和芳烃的催化区域选择性官能化

• 批准号: 1156496
• 负责人: John Hartwig
• 金额: $ 35.14万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1156496&HistoricalAwards=false
• 关键词: Catalytic; Regioselective; Functionalization; Alkane; Arenes

This research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor John F. Hartwig at the University of Illinois at Urbana-Champaign to develop reactions at typically unreactive C-H bonds. This work will create new methods to prepare organic molecules by selective chemical transformations at positions that are inert to most reagents. Complexes containing bonds between transition metals and boron catalyze these reactions, and this grant will reveal the properties of the transition metal that lead to this unusual reactivity. The reactions catalyzed by these complexes have been and will continue to be applied to the synthesis of polymers containing new properties, organic molecules with enhanced abilities to emit light, components of catalysts for other reactions, and organic probes for understanding biological systems. Work emanating from the proposed research is part of new curricula for the classroom, short-courses, many external lectures, and a major textbook project that will be completed in the next grant period by the PI.This research will lead to new methods to conduct chemical synthesis in fewer steps, with less waste, and with less reliance on the installation and protection of functional groups. In addition, this research creates the underlying principles on which future design of catalysts and processes for more efficient synthesis are based. Studies to define how the electronic properties of the metal and how electrophilic or nucleophilic properties of the reactive ligand affect C-H bond cleavage and functionalization will create these principles.

该研究奖在伊利诺伊大学Urbana-Champaign大学的John F. Hartwig教授的工作中支持无机，生物有机和有机金属化学计划，该奖项在Urbana-Champaign大学的工作，以在典型的不反应性C-H债券上发展反应。 这项工作将创建新的方法来制备有机分子，这是通过在大多数试剂上惰性的位置的选择性化学转化来制备有机分子的。 含有过渡金属和硼之间的键的复合物催化了这些反应，该赠款将揭示导致这种异常反应性的过渡金属的特性。 这些复合物催化的反应已经并且将继续应用于包含新特性的聚合物，具有增强能力的有机分子的聚合物，发射光的能力，其他反应的催化剂成分以及用于了解生物学系统的有机探针。 拟议的研究发出的工作是课堂，短巡带，许多外部讲座的新课程的一部分，以及一个主要的教科书项目，该项目将在下一个赠款期间由PI完成。这项研究将导致新的方法在更少的较少的步骤中进行化学合成，并且较少的废物对功能组的安装和保护组的依赖性较小，并且对功能型组的安装和保护。 此外，这项研究创造了基本原则，以使催化剂和过程的未来设计以更有效的合成为基础。 定义金属的电子特性以及反应性配体的亲电或亲核特性如何影响C-H键裂解和功能化将如何创建这些原理。