CAREER: New Reagents and Strategies for Catalytic Nucleophilic Fluorination

职业：催化亲核氟化的新试剂和策略

• 批准号: 1148750
• 负责人: Abigail Doyle
• 金额: $ 55万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1148750&HistoricalAwards=false
• 关键词: CAREER; New; Reagents; Strategies; Catalytic

With this CAREER Award, the Chemical Synthesis Program is supporting the research of Professor Abigail G. Doyle of Princeton University to invent new reagents and strategies for nucleophilic fluorination. The first objective of this research is to develop Lewis base-catalyzed hydrofluorinations using benzoyl fluoride as a latent fluoride source. The second objective is to design catalytic methods for the regio- and stereoselective synthesis of allylic and benzylic fluorides. The research is expected to facilitate the discovery and manufacture of pharmaceutical agents, agrochemicals, and functional materials by enabling the preparation of novel fluorinated building blocks using inexpensive and readily available fluoride sources. Knowledge accrued through these investigations should give way to a better understanding of the impact of aliphatic fluorine substitution in biomedical and basic research and afford new opportunities for reaction design. Professor Doyle will also be initiating educational outreach projects that interweave research and teaching. The impact of the education plan will be to broaden participation in STEM fields, particularly by underrepresented minorities and women, through early engagement of these students in hands-on research activities. One program involves providing students from a Trenton-area community college that serves a diverse population, including underrepresented minorities and low-income students, the opportunity to pursue research as part of their honors chemistry curriculum in Professor Doyle's laboratory. Second, the student invited lecture series at Princeton will be expanded to include speakers from industry, primarily undergraduate institutions, and government agencies to expose students to more varied career opportunities in the STEM disciplines.

凭借这一职业奖，化学合成项目正在支持普林斯顿大学 Abigail G. Doyle 教授的研究，以发明亲核氟化的新试剂和策略。这项研究的第一个目标是开发使用苯甲酰氟作为潜在氟化物源的路易斯碱催化氢氟化反应。第二个目标是设计用于烯丙基氟化物和苄基氟化物的区域和立体选择性合成的催化方法。该研究有望通过使用廉价且容易获得的氟化物源制备新型氟化结构单元，从而促进药剂、农用化学品和功能材料的发现和制造。通过这些研究积累的知识应该有助于更好地理解脂肪族氟取代在生物医学和基础研究中的影响，并为反应设计提供新的机会。多伊尔教授还将启动研究和教学相结合的教育推广项目。该教育计划的影响将是通过让学生尽早参与实践研究活动，扩大对 STEM 领域的参与，特别是代表性不足的少数族裔和女性。其中一项计划包括为特伦顿地区一所社区学院的学生提供在多伊尔教授实验室进行研究的机会，该社区学院为多元化人群（包括代表性不足的少数族裔和低收入学生）进行研究，作为他们的荣誉化学课程的一部分。其次，普林斯顿大学的学生邀请讲座系列将扩大到包括来自工业界（主要是本科院校）和政府机构的演讲者，让学生在 STEM 学科中获得更多样的职业机会。