SNM: Electronically Controlled Surface Assembly of DNA Nanostructures

SNM：DNA 纳米结构的电子控制表面组装

• 批准号: 1120890
• 负责人: William Goddard
• 金额: $ 125万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1120890&HistoricalAwards=false
• 关键词: SNM; Electronically; Controlled; Surface; Assembly

The goal of this Scalable NanoManufacturing (SNM) project is to develop a scalable and inexpensive process for manufacturing integrated systems of DNA constructed nanodevices and metamaterials. Structural DNA nanotechnology is unique in its ability to arrange nanomaterials such as carbon nanotubes, proteins, quantum dots, and metal nanoparticles into arbitrary varieties of rationally designed nanoscale geometries. Some such structures have already demonstrated potential as sensors, transistors, optical components, nanomechanical manipulators, and experimental platforms for basic science. Because DNA nanostructures are self-assembled, it is possible in principle to cheaply produce large quantities of future nanodevices for widespread technological application. The key challenge is the integration of these devices into functioning systems in a way that is compatible with mass manufacturing. At present, there is no viable technological vision for doing so, very limited pertinent knowledge regarding the issues and challenges, and limited efforts in addressing these problems by researchers in the field. The aim is to remedy this situation by combining the development of more versatile DNA based nanostructures with the exploration of entirely novel concepts for electronically monitoring and controlling the assembly of DNA nanostructure arrays. Another aim is to improve qualitatively our ability to interface DNA nanostructures with functional nanoscale materials and provide powerful new ways to monitor and guide DNA based self-assembly. This project is based on DNA nanostructures that will undergo surface initiated self-assembly into much larger 2D and 3D arrays. The long term vision is a bench-top factory, in which functional nanomaterials such as carbon nanotubes and proteins are assembled with the help of DNA into high quality nanostructures arranged according to a macroscale system layout. Assembly will be monitored both electronically and optically to allow real time assembly optimization and error control. The finished product will be printed onto low cost substrates for sophisticated functions such as disease diagnosis. The broader impact of this project includes cost-effective manufacturing of large scale functional nanomaterials, as well as a comprehensive education and outreach program including the mentoring of graduate students, undergraduates and K-12 students, including underrepresented groups. In addition to direct mentoring of graduate and undergraduate students, the PIs have a strong record of outreach activities, which will be continued and expanded during the proposal work period. This includes participation in programs to engage high school teachers in research related activities (UCR), playing a vital role in Quality Education for Minorities (QEM) and Minorities in Mathematics, Science, and Engineering (MSE) programs at Caltech, and involving high school students in nanotechnology research and close collaboration with scientifically-oriented arts and entertainment groups (NYU).

该可扩展纳米制造 (SNM) 项目的目标是开发一种可扩展且廉价的工艺，用于制造 DNA 构建的纳米器件和超材料的集成系统。 结构DNA纳米技术的独特之处在于它能够将碳纳米管、蛋白质、量子点和金属纳米粒子等纳米材料排列成任意种类的合理设计的纳米级几何形状。 一些此类结构已经显示出作为传感器、晶体管、光学元件、纳米机械操纵器和基础科学实验平台的潜力。由于 DNA 纳米结构是自组装的，因此原则上可以廉价地生产大量未来纳米器件以实现广泛的技术应用。 关键的挑战是以与大规模制造兼容的方式将这些设备集成到功能系统中。 目前，还没有可行的技术愿景来实现这一目标，有关问题和挑战的相关知识非常有限，并且该领域的研究人员在解决这些问题方面的努力也有限。 其目的是通过将更通用的基于 DNA 的纳米结构的开发与电子监测和控制 DNA 纳米结构阵列组装的全新概念的探索相结合来解决这种情况。 另一个目标是提高我们将 DNA 纳米结构与功能性纳米材料连接的能力，并提供强大的新方法来监控和指导基于 DNA 的自组装。 该项目基于 DNA 纳米结构，该结构将通过表面启动自组装成更大的 2D 和 3D 阵列。长期愿景是建立一个台式工厂，在 DNA 的帮助下将碳纳米管和蛋白质等功能性纳米材料组装成根据宏观系统布局排列的高质量纳米结构。装配将通过电子和光学方式进行监控，以实现实时装配优化和错误控制。成品将被打印到低成本基材上，以实现疾病诊断等复杂功能。该项目的更广泛影响包括大规模功能纳米材料的经济高效制造，以及全面的教育和推广计划，包括对研究生、本科生和 K-12 学生（包括代表性不足的群体）的指导。除了对研究生和本科生的直接指导外，PI 还拥有良好的外展活动记录，这些活动将在提案工作期间继续并扩大。这包括参与让高中教师参与研究相关活动 (UCR) 的计划，在加州理工学院少数族裔优质教育 (QEM) 和数学、科学和工程中的少数族裔 (MSE) 计划中发挥重要作用，并让高中参与纳米技术研究的学生以及与科学导向的艺术和娱乐团体（纽约大学）的密切合作。