SNM: Continuous and Scalable Nanomanufacturing for 3-Dimensional Functional Biomedical Devices

SNM：连续且可扩展的 3 维功能生物医学设备纳米制造

• 批准号: 1120795
• 负责人: Shaochen Chen
• 金额: $ 130万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1120795&HistoricalAwards=false
• 关键词: SNM; Continuous; Scalable; Nanomanufacturing; Dimensional

Diabetes, heart failure, and hepatic failure are diseases of enormous burden to Americans. The effective therapies for these often lethal diseases require the application of novel engineering concepts and technologies. Tissue engineering holds great promise for the treatment of these diseases. Using biodegradable scaffolds, cells are organized in close proximity to each other with a well-defined 3-dimensional (3D) space for the formation of new tissues. While a typical biological cell has a size of several microns, the interactions of cells with the environment occur at a nanoscale. Fabricating such scaffolds with micro- and nano-scale features has been a significant bottleneck for industrial scale production of tissues. The goal of this research is to develop a novel nanomanufacturing system, Hyperlens-Assisted Projection Stereolithography (HAPS), with a sub-50 nm resolution for the direct-write of 3D, heterogeneous biological scaffolds. The research tasks include: a) design and fabrication of the hyperlens by combining simulation with experiments, b) integration of the hyperlens with the projection stereolithography system, c) design and fabrication of complex tissue scaffolds, and d) studying the growth and phenotypical modulation of vascular endothelial cells and smooth muscle cells using the scaffolds.If successful, this project will help to enhance the emerging US biomanufacturing industry for the production of vascular tissues, skins, bones, and other tissues and organs. The proposed HAPS technique will foster a giant step for scalable, continuous 3D nanomanufacturing of not only functional biomedical devices, but also 3D nanoelectronics, nanophotonics, and nanoenergy devices. Moreover, the results of this work will provide inspiring teaching materials and interesting laboratory projects. The proposed efforts of integrating research with education will offer undergraduates and graduate students increased exposure to nanomanufacturing. The proposed symposia and workshop will greatly enhance the impact of nanomanufacturing research.

糖尿病，心力衰竭和肝衰竭是给美国人带来巨大负担的疾病。这些经常致命疾病的有效疗法需要应用新颖的工程概念和技术。组织工程对治疗这些疾病有很大的希望。使用可生物降解的支架，细胞彼此紧密地组织，并有明确的3维（3D）空间，以形成新组织。虽然典型的生物细胞的大小为几微米，但细胞与环境的相互作用发生在纳米级。用微型和纳米尺度的特征制造这种脚手架是组织生产组织的重要瓶颈。这项研究的目的是开发一种新型的纳米制造系统，超长辅助的投影立体光刻（HAPS），并以3D的直接作用，异质生物支架的直接定位分辨率低于50 nm。 The research tasks include: a) design and fabrication of the hyperlens by combining simulation with experiments, b) integration of the hyperlens with the projection stereolithography system, c) design and fabrication of complex tissue scaffolds, and d) studying the growth and phenotypical modulation of vascular endothelial cells and smooth muscle cells using the scaffolds.If successful, this project will help to enhance the emerging US biomanufacturing industry for the血管组织，皮肤，骨骼以及其他组织和器官的产生。拟议的HAP技术将促进对功能性生物医学设备的可扩展，连续3D纳米制造的巨大步骤，还可以为3D纳米电子学，纳米光子和纳米器设备提供巨大的步骤。此外，这项工作的结果将提供鼓舞人心的教材和有趣的实验室项目。将研究与教育融合的拟议努力将为大学生提供，研究生增加了对纳米制造的影响。拟议的研讨会和研讨会将大大增强纳米制造研究的影响。