RAPID: A unique opportunity to preserve a genetic record of the origin of a novel host-pathogen interaction

RAPID：保存新型宿主-病原体相互作用起源的遗传记录的独特机会

• 批准号: 1113666
• 负责人: Geoffrey Hill
• 金额: $ 4万
• 依托单位: Auburn University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1113666&HistoricalAwards=false
• 关键词: RAPID; unique; opportunity; preserve; genetic

Mycoplasma gallisepticum (MG) is a widespread bacterial pathogen of chickens and turkeys that jumped to House Finches in eastern North America in 1994. For the past 16 years, this new songbird disease has been restricted in range to the east and Pacific Northwest of North America, but the pathogen is now spreading as an epizootic through the southwestern range of the House Finch. The purpose of the proposed research is to document this new outbreak of MG by collecting cultures of MG and archiving genome and transcriptome samples from finches during the first year of the appearance of MG in House Finches in Tempe, Arizona. This award will create a valuable set of samples for future research. By screening for genes that show rapid evolutionary change in both the host and the pathogen, it will be possible to identify those genes that are the central players in the host and pathogenicity by MG. The project will promote science education through the involvement of undergraduate students and include outreach to the general public about studies of MG at backyard feeding stations.

Mycoplasma gallisepticum (MG) is a widespread bacterial pathogen of chickens and turkeys that jumped to House Finches in eastern North America in 1994. For the past 16 years, this new songbird disease has been restricted in range to the east and Pacific Northwest of North America, but the pathogen is now spreading as an epizootic through the southwestern range of the House Finch.拟议的研究的目的是通过在亚利桑那州坦佩市芬奇（House Finches）出现MG的第一年中收集MG和归档基因组和转录样品的文化来记录MG的新爆发。该奖项将为未来的研究创建一套宝贵的样本。通过筛选显示出宿主和病原体快速进化变化的基因，可以识别那些基因，这些基因是宿主中的主要参与者和MG致病性的基因。该项目将通过本科生的参与来促进科学教育，并在后院喂养站向公众提供有关MG研究的宣传。