CAREER: Expanding the Structural Complexity and Functional Repertoire of Sequence-Specific Polyamide Oligomers

职业：扩展序列特异性聚酰胺低聚物的结构复杂性和功能库

• 批准号: 1056520
• 负责人: Amelia Fuller
• 金额: $ 44.6万
• 依托单位: Santa Clara University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1056520&HistoricalAwards=false
• 关键词: CAREER; Expanding; Structural; Complexity; Functional

The Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation supports Professor Amelia Fuller of Santa Clara University, for the synthesis and physiochemical analyses of peptoid and extended peptoid polyamides using bound solvatochromic dyes and biarsenical fluorophores. The goals of this research are to understand intramolecular assembly as a function of peptoid structure, and to discover new peptoids with tertiary and quaternary structure. Screening of efficiently synthesized peptoid libraries will lead to rapid evaluation of both inter- and intra molecular association events, allowing facile identification of motifs leading to higher-order structures. Molecules showing interesting association and folding properties will be used for drug discovery studies through a public online database (D3).Broader impacts of the research include opportunities for undergraduate students to get involved in research in organic synthesis, combinatorial screening methods, and even anti-microbial activity testing in a microbiology laboratory. Professor Fuller has created a unique opportunity at her institution to integrate her research activities directly into both chemistry and biology teaching environments during the academic year. In addition to yearlong research projects, independent summer projects are also planned.

国家科学基金会化学部的化学结构，动力学和机制计划支持圣塔克拉拉大学的Amelia Fuller教授，使用绑定的溶剂化染色体染料和Biarsenicalialicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalicalial completot和扩展的肽聚酰胺进行合成和生理化学分析。 这项研究的目标是理解分子内组件是肽结构的函数，并发现具有第三和第四纪结构的新肽。 有效合成的肽文库的筛查将导致分子间和分子内结合事件的快速评估，从而使导致高阶结构的基序易于识别。 表现出有趣关联和折叠特性的分子将通过公共在线数据库进行药物发现研究（D3）。研究的影响包括本科生的机会，有机会参与有机合成，组合筛查方法，甚至反 - 微生物实验室中的微生物活性测试。 富勒教授在她的机构中创造了一个独特的机会，将她的研究活动直接纳入学年的化学和生物学教学环境中。 除了一年的研究项目外，还计划了独立的夏季项目。