RUI: Rational design of cysteinyl peptide ligands as chelators of mercury (II)

RUI：作为汞螯合剂的半胱氨酰肽配体的合理设计（II）

• 批准号: 1011859
• 负责人: Maria Ngu-Schwemlein
• 金额: $ 23.3万
• 依托单位: Winston-Salem State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1011859&HistoricalAwards=false
• 关键词: RUI; Rational; design; cysteinyl; peptide

This award in the Chemical Synthesis (SYN) program in the Division of Chemistry supports work by Professors Maria Ngu-Schwemlein, John Merle, and Sayo Fakayode at Winston-Salem State University to carry out fundamental studies on the rational design and synthesis of peptide derived binding agents for the toxic mercury(II) ion. Evaluating the mercury(II) binding affinity of some cysteine-containing peptides will reveal the selectivity and thermodynamic factors that are important in assessing their mode(s) of interaction. Correlations between the chemical structures of some cysteinyl peptide ligands and their binding activity for mercury(II) will be explored by microcalorimetric measurements, and identification of the binding specificity will be conducted by a combination of theoretical calculations and solid state studies. Additionally, the molecular interactions of these compounds with some biological molecules will be monitored by spectroscopic measurements. Selective and effective mercury(II) binding agents are extremely useful for the development of mercury(II) trapping agents for chelation therapy of mercury poisoning.This interdisciplinary research study will enhance the research environment of the chemistry department at Winston-Salem State University in preparing undergraduates, primarily underrepresented groups at this historically black institution, for entry into advanced degree programs and careers in science. This research may also afford a basis for subsequent research in the environmental and health sciences such as the development of microsensors for monitoring toxic and harmful metal ions in environmental and biological samples. Additionally, this research may provide useful peptides for future application in genetically engineered plants that are useful for phytoremediation of mercury(II) pollution in soil or watersheds.

在化学综合（SYN）的化学裁定计划中，该奖项支持Winston-Salem State University的Maria Ngu-Schwemlein，John Merle和Sayo Fakayode教授的工作，以对肽衍生的结合物进行理性设计和合成有毒的Mercury（ii）iro的肽衍生粘合剂的合成。 评估某些含半胱氨酸的肽的汞结合亲和力（II）将揭示在评估其相互作用模式很重要的选择性和热力学因素。 某些半胱氨酸肽配体的化学结构与汞的结合活性（II）之间的相关性将通过微钙化测量来探索，并且结合特异性的鉴定将通过理论计算和固态研究的结合进行。 另外，这些化合物与某些生物分子的分子相互作用将通过光谱测量来监测。 选择性和有效的汞（II）结合剂对于汞中汞中毒的螯合剂的开发非常有用。这项跨学科的研究将增强温斯顿 - 塞勒姆州立大学化学系的化学研究环境，以准备本科生的本科生，主要是在这个历史悠久的黑人Intervortions中，以培养了这个历史悠久的黑人学位，以供高级培训培训，并在高级培训中进行了研究。 这项研究还可能为随后在环境和健康科学方面进行研究的基础，例如开发微观传感器，以监测环境和生物样品中有毒和有害金属离子。 此外，这项研究可能为未来在基因工程植物中应用提供有用的肽，这些肽可用于土壤或流域中汞（II）污染的植物修复（II）。