Peptide Based Macrocycles as Chemosensors for Metal Ions

基于肽的大环化合物作为金属离子的化学传感器

• 批准号: 0071632
• 负责人: Maria Ngu-Schwemlein
• 金额: $ 16.11万
• 依托单位: Southern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0071632&HistoricalAwards=false
• 关键词: Peptide; Based; Macrocycles; Chemosensors; Metal

This project has as its long-term goal the development of chemosensing molecules that bind metal ions and signal specific metal ion binding. The specific aims of this study are to design and synthesize peptide derived macrocyclic ligands with an intrinsic fluorescent signal to indicate metal ion binding. The strategy is to employ peptide based macrocycles incorporating intrinsic signalling molecules that display a fluorescence response. The ion binding selectivities will be comparatively studied by NMR, CD, potentiometry and fluorescence techniques. Ground state properties of these macrocycles, in the solid state as well as in solution, will be investigated by X-ray diffraction methods, NMR and conformational analysis.With this Award, the Organic and Macromolecular Chemistry Program's Organic Dynamics Program supports the research of Professor Maria Ngu-Schwemlein of Southern University. Professor Ngu-Schwemlein proposes to study the interactions between metal ions and small molecules that are modeled on proteins. With a detectable interaction between these molecules and specific ions, applications toward ion selective sensors, ion chromatography, and metal ion detoxification will be possible.

该项目的长期目标是结合金属离子并信号特异性金属离子结合的化学传感分子的发展。 这项研究的具体目的是设计和合成具有内在荧光信号的肽衍生的大环配体，以指示金属离子结合。 该策略是采用基于肽的大环，其中包含显示荧光反应的固有信号分子。 NMR，CD，电位测定法和荧光技术将对离子结合选择性进行比较研究。 这些大环和溶液中这些大环的基态特性将通过X射线衍射方法，NMR和构象分析进行研究。在此奖项中，有机和大分子化学计划的有机动力学计划支持南方大学Maria Ngu-Schwemin教授的研究。 Ngu-Schwemlein教授建议研究以蛋白质建模的金属离子与小分子之间的相互作用。 通过这些分子与特定离子之间可检测的相互作用，可以进行离子选择传感器，离子色谱和金属离子排毒的应用。