CAREER: The Sensory Biomechanics of the Lateral Line System

职业：侧线系统的感觉生物力学

• 批准号: 0952344
• 负责人: Matthew McHenry
• 金额: $ 70.36万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-15 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0952344&HistoricalAwards=false
• 关键词: CAREER; Sensory; Biomechanics; Lateral; Line

Fish have a remarkable ability to detect the strike of a predator by sensing water flow with receptors within the skin. The major aim of this research project is to understand the mechanics of this sensory system, known as the lateral line, in zebrafish larvae (Danio rerio). This will be achieved by using a novel combination of mathematical modeling, behavioral experiments, and flow visualization techniques developed for aeronautical engineering. These approaches will consider how the shape of the body and the direction of a stimulus influence the ability of a fish to evade a predator. The proposed research will advance understanding in two major areas. First, this work will establish the mechanics of a sensory system that is critical to the ecology of a broad diversity of aquatic animals. Second, this work will define relationships between mechanosensory inputs and behavioral outputs in a major model system for neuroscience. This will inform our understanding of how vertebrate behavior is affected by the integration of mechanosensory information. This research project will also involve outreach and education. The investigators propose a novel K-12 educational program in collaboration with local schools and the U.C. Irvine Department of Education. The PI and his students will also participate in a number of outreach programs at U.C. Irvine that are designed to enhance involvement of minority researchers and education to underserved local schools.

鱼类具有通过皮肤内的感受器感知水流来检测捕食者攻击的非凡能力。该研究项目的主要目的是了解斑马鱼幼虫（Danio rerio）的这种感觉系统（称为侧线）的机制。这将通过使用为航空工程开发的数学建模、行为实验和流动可视化技术的新颖组合来实现。这些方法将考虑身体的形状和刺激的方向如何影响鱼躲避捕食者的能力。拟议的研究将增进对两个主要领域的理解。首先，这项工作将建立对多种水生动物的生态至关重要的感觉系统的机制。其次，这项工作将定义神经科学主要模型系统中机械感觉输入和行为输出之间的关系。这将使我们了解机械感觉信息的整合如何影响脊椎动物的行为。该研究项目还将涉及外展和教育。研究人员与当地学校和加州大学合作提出了一项新颖的 K-12 教育计划。尔湾教育部。 PI 和他的学生还将参加加州大学伯克利分校的一些外展项目。尔湾，旨在加强少数族裔研究人员的参与以及对服务不足的当地学校的教育。