Group-Transfer Reactions of Low-Coordinate Nickel

低配位镍的基团转移反应

• 批准号: 0957816
• 负责人: Gregory Hillhouse
• 金额: $ 48.72万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0957816&HistoricalAwards=false
• 关键词: Group; Transfer; Reactions; Low; Coordinate

This award in the Chemical Synthesis (SYN) program supports work by Professor Gregory Hillhouse at the University of Chicago to carry out fundamental studies on the coordination and organometallic chemistry of two- and three-coordinate nickel in various oxidation states. The general theme of the research is centered on the exploration of group-transfer reactions of Ni, particularly those involving nitrene, carbene, and oxo functional groups, and is focused on both understanding fundamental mechanistic details of new group-transfer reactions and in developing catalytic methods for effecting these transformations. The chemistry of 2-coordinate complexes of Ni will be developed, including synthetic approaches to 2-coordinate complexes featuring multiple metal-ligand bonding. Key targets include complexes with open-shell electronic configurations and non-integer Ni=E bond orders.This research will provide a solid, fundamental understanding of the chemistry of group transfer reactions involving nickel and will impact applied areas of inorganic chemistry and catalysis, as well as organic synthesis. This research will also provide basic insight into the chemistry of Ni(I) and Ni(III), rare oxidation states but of emerging importance in the catalytic and biological chemistry of nickel. In addition to the scientific contributions, this project will contribute to human resource development and the training of the next generation of scientists and teachers, empowering young coworkers to make seminal contributions to US academic and industrial chemical research endeavors. The research team will include scientists at all educational levels: faculty, postdoctoral researchers, and graduate, undergraduate, and high-school students. Participation of underrepresented minorities, which in the past have included Hispanic, African-American, sight-disabled, and women coworkers, will be actively encouraged.

该化学合成（SYN）项目奖项支持芝加哥大学 Gregory Hillhouse 教授的工作，以开展各种氧化态下的二配位和三配位镍的配位和有机金属化学的基础研究。该研究的总体主题集中在探索镍的基团转移反应，特别是那些涉及氮宾、卡宾和氧代官能团的反应，重点是了解新基团转移反应的基本机制细节和开发催化实现这些转变的方法。将开发 Ni 2 配位配合物的化学，包括具有多重金属-配体键合特征的 2 配位配合物的合成方法。主要目标包括具有开壳层电子构型和非整数 Ni=E 键序的配合物。这项研究将为涉及镍的基团转移反应的化学提供坚实、基础的理解，并将影响无机化学和催化的应用领域，例如还有有机合成。这项研究还将提供对 Ni(I) 和 Ni(III) 化学的基本见解，它们是罕见的氧化态，但在镍的催化和生物化学中具有新兴的重要性。除了科学贡献外，该项目还将有助于人力资源开发以及下一代科学家和教师的培训，使年轻同事能够为美国学术和工业化学研究工作做出开创性贡献。研究团队将包括各个教育层次的科学家：教师、博士后研究人员以及研究生、本科生和高中生。将积极鼓励代表性不足的少数群体（过去包括西班牙裔、非裔美国人、视力障碍者和女同事）的参与。