CAREER: Merging Adjacent Areas of Lanthanide Chemistry to Study Catalysis

职业：合并稀土化学的相邻领域以研究催化

• 批准号: 0955000
• 负责人: Matthew Allen
• 金额: $ 60万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-15 至 2016-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0955000&HistoricalAwards=false
• 关键词: CAREER; Merging; Adjacent; Areas; Lanthanide

With the support of the Chemical Catalysis Program in the Chemistry Division, Professor Matthew J. Allen of the Chemistry Department at Wayne State University will focus on the testing of hypotheses regarding the influence of anion dissociation and water coordination on catalysis and the synthesis of a new series of precatalysts modeled after lanthanide-based contrast agents for MRI. Additionally, the methods available to study dynamic structure-activity relationships of lanthanide-based precatalysts in aqueous systems will be greatly expanded through adaptation of luminescence-decay measurements and Oxygen-17 NMR spectroscopy. Furthermore, the data obtained using these techniques will be used to aid in the testing of hypotheses regarding the mechanistic influence of water coordination on asymmetric bond formation in the Mukaiyama aldol reaction using a series of new chiral precatalysts.As a broader impact of the proposed research, Professor Allen will study the Mukaiyama aldol reaction because it is one of the most significant carbon-carbon bond-forming reactions, which are of paramount importance to synthetic chemistry. In addition to probing important problems in lanthanide-based catalysis, this proposal describes plans to improve education by mentoring early scientists and incorporating communication skills into scientific curricula. Specifically, year-round research experiences directly related to the scientific portion of this proposal will be provided for high school students from diverse educational and socioeconomic backgrounds, which are expected to have great impact on the propensity of students to pursue careers in science. Additionally, because communication skills are critical to a successful scientific career but are often underemphasized in science education, plans are outlined describing the integration of communication instruction into mentoring experiences and formal science courses at the university and high school levels. These programs will greatly enhance the otherwise standard science education of those who participate by more thoroughly preparing students for careers in science.

在化学系化学催化项目的支持下，韦恩州立大学化学系的Matthew J. Allen教授将重点测试有关阴离子解离和水配位对催化的影响的假设，并合成一种新的催化剂。系列仿照用于 MRI 的镧系元素造影剂建模的预催化剂。此外，通过采用发光衰变测量和 Oxygen-17 NMR 光谱，可大大扩展可用于研究含水体系中基于镧系元素的预催化剂的动态结构-活性关系的方法。此外，使用这些技术获得的数据将用于帮助测试有关水配位对使用一系列新型手性预催化剂的 Mukaiyama 羟醛反应中不对称键形成的机械影响的假设。艾伦教授将研究Mukaiyama羟醛反应，因为它是最重要的碳-碳键形成反应之一，对合成化学至关重要。除了探讨基于镧系元素的催化的重要问题外，该提案还描述了通过指导早期科学家并将沟通技巧纳入科学课程来改善教育的计划。具体来说，将为来自不同教育和社会经济背景的高中生提供与该提案的科学部分直接相关的全年研究经验，预计这将对学生追求科学职业的倾向产生重大影响。此外，由于沟通技能对于成功的科学事业至关重要，但在科学教育中往往被低估，因此概述了将沟通教学纳入大学和高中水平的指导经验和正式科学课程的计划。这些项目将通过让学生为科学职业做更彻底的准备，极大地提高参与者的标准科学教育。