Genome-level resolution of species boundaries and phylogeny of the North American tiger salamander radiation

北美虎蝾螈辐射的物种边界和系统发育的基因组水平分辨率

• 批准号: 0949532
• 负责人: David Weisrock
• 金额: $ 45万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0949532&HistoricalAwards=false
• 关键词: Genome; level; resolution; species; boundaries

Tiger salamanders are used in a range of biological and biomedical research, with much emphasis placed on a single species, the Mexican Axolotl, due to ease of rearing and experimental manipulation. However, this species is just one representative of a large and diverse radiation of tiger salamanders. Collectively, this group can serve as a model system for research ranging from speciation to regeneration, but little is known about how many species actually exist and little is known about their natural history, evolution, development, and relationships. This research will leverage new molecular technologies and existing genetic data to provide a comprehensive assessment of tiger salamander species diversity across North America and place these species into a comparative framework to understand their evolution. Concurrently, there will be development of new statistical tools to identify genes that have been uniquely influenced by other factors, such as natural selection.This research forges a strong link between statistical and biological research programs, an increasingly important form of collaboration as Biology moves further into the realm of genomics. Support and training of human resources will be provided at the postdoctoral and graduate level and persons employed by this grant will be integrated into a modern and multidisciplinary research program. This work will result in the collection of one of the largest set of genetic data at the level of populations for a naturally distributed organism.

Tiger Salamanders用于一系列生物学和生物医学研究中，由于易于饲养和实验性操纵，因此对单个物种，即墨西哥Axolotl进行了很多重视。 但是，该物种只是老虎sal的大型辐射的代表。 总的来说，该群体可以作为从物种到再生的研究模型系统，但对实际存在多少物种知之甚少，对它们的自然历史，进化，发展和关系知之甚少。 这项研究将利用新的分子技术和现有的遗传数据，以全面评估北美的老虎萨拉曼物种多样性，并将这些物种置于比较框架中，以了解其进化。同时，将开发新的统计工具，以识别受到其他因素（例如自然选择）独特影响的基因。这项研究在统计和生物学研究计划之间建立了牢固的联系，这是一种越来越重要的合作形式，随着生物学的进一步发展，合作的形式越来越重要。进入基因组学领域。 人力资源的支持和培训将在博士后和研究生层面提供，该赠款雇用的人员将纳入现代和多学科的研究计划。 这项工作将导致收集自然分布生物体种群中最大的遗传数据之一。