Research Starter Grant: VIRAL INDUCTION OF GROWTH ANOMALIES IN CORAL

研究启动资金：病毒诱导珊瑚生长异常

• 批准号: 0925454
• 负责人: Rebecca Vega
• 金额: $ 5万
• 依托单位: Florida International University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0925454&HistoricalAwards=false
• 关键词: Research; Starter; Grant; VIRAL; INDUCTION

Corals are important components of reefs, providing food and habitat to thousands of tropical species. In the last few decades, disease outbreaks have led to significant reductions in coral populations worldwide, yet almost nothing is known about the viruses that infect corals. This project will collect new data on the types of viruses in corals and evaluate the effects of viral infection on reefs. Specifically, the investigators will address the hypothesis that viruses (most notably herpes-like viruses) infect and cause tumors or growth anomalies (GAs) on Pacific reef building corals. Using next generation genomic technology, investigators will use gene sequences to compare and contrast the viral types found in healthy corals to those contained within tumors. This novel approach will not only determine if these diseases are the result of viral infection and transformation, but will also generate new data on a group of unknown viruses and provide insight into viral evolution. The project is will also provide data that can better inform policy makers about how to control viral outbreaks including limiting the spread of infection and disease on coral. Additionally, previously identified coral viruses are distantly related to human herpesviruses, and this continued project will help further evaluate the function and mechanism of herpes viral infection, including how they infect tissues and cause tumor formation in animals. Finally, this project will begin the training of several young female scientists as part of their graduate education; providing them funds to conduct their research and allowing them to present their work at international and domestic conferences.

珊瑚是礁石的重要组成部分，为数千种热带物种提供食物和栖息地。在过去的几十年中，疾病暴发导致全球珊瑚种群的大幅减少，但几乎没有感染珊瑚的病毒。该项目将收集有关珊瑚病毒类型的新数据，并评估病毒感染对礁石的影响。具体而言，研究人员将解决以下假设：病毒（最著名的是类似疱疹病毒）并在太平洋礁建筑珊瑚上引起肿瘤或生长异常（气体）。使用下一代基因组技术，研究人员将使用基因序列比较和对比健康珊瑚中发现的病毒类型与肿瘤中的病毒类型。这种新颖的方法不仅将确定这些疾病是否是病毒感染和转化的结果，而且还将生成一组未知病毒的新数据，并提供对病毒进化的见解。该项目还将提供数据，可以更好地告知政策制定者如何控制病毒爆发，包括限制感染和疾病在珊瑚上的传播。此外，先前鉴定出的珊瑚病毒与人类疱疹病毒密切相关，该持续项目将有助于进一步评估疱疹病毒感染的功能和机制，包括它们如何感染组织和引起动物的肿瘤形成。最后，该项目将开始对几位年轻女科学家进行培训，作为其研究生教育的一部分。为他们提供资金来进行研究，并允许他们在国际和国内会议上展示自己的作品。