New Approaches to Catalyst Screening and Development

催化剂筛选和开发的新方法

• 批准号: 0911732
• 负责人: Stephen DiMagno
• 金额: $ 43.5万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911732&HistoricalAwards=false
• 关键词: New; Approaches; Catalyst; Screening; Development

This project will continue work on the development of catalyst screening methods that employ enzymes as the analytical sensors. This approach has been labeled In Situ Enzymatic Screening (ISES). While chromatographic screening methods are established, these are normally run as serial, time point assays, requiring aliquot removal and work-up, prior to analysis. The ISES method offers the possibility to obtain parallel, real time estimates of relative reaction rates and, in ideal cases, sense and magnitude of enantio-induction, without the need to install a chromophore or mass tag in the substrate. A key goal of the next cycle of this project is to enhance the throughput of the ISES screening, such that larger matrices of potential catalytic combinations may be screened. Also important will be to further develop the most interesting catalysts uncovered in the last cycle, including carbohydrate-based chiral salen ligands, and new combinations of late transition metal halides for formal halocarbocyclization processes. In addition, further expansion of the scope of chemistry that is amenable to screening via ISES will be investigated.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor David B. Berkowitz in the Department of Chemistry at the University of Nebraska. Professor Berkowitz's research efforts include the development of useful new catalysts for the stereo-controlled opening of small ring compounds, and for carbon-halogen and carbon-carbon bond formation. Successful development of the methodology will have an impact on synthesis in both the academic and industrial communities, the latter particularly in the combinatorial catalysis and pharmaceutical process areas.

该项目将继续致力于开发使用酶作为分析传感器的催化剂筛选方法。 这种方法被称为原位酶筛选 (ISES)。 虽然建立了色谱筛选方法，但这些方法通常作为连续的时间点测定运行，需要在分析之前取出等分试样并进行后处理。 ISES 方法提供了获得相对反应速率的并行、实时估计的可能性，并且在理想情况下，获得对映感应的意义和大小，而无需在底物中安装发色团或质量标签。 该项目下一个周期的一个关键目标是提高 ISES 筛选的通量，以便可以筛选更大的潜在催化组合矩阵。 同样重要的是进一步开发上一个循环中发现的最有趣的催化剂，包括基于碳水化合物的手性萨伦配体，以及用于正式卤碳环化过程的后过渡金属卤化物的新组合。 此外，还将研究进一步扩大可通过 ISES 筛选的化学范围。有机和高分子化学项目通过该奖项支持英国大学化学系 David B. Berkowitz 教授的研究内布拉斯加州。 Berkowitz 教授的研究工作包括开发有用的新型催化剂，用于小环化合物的立体控制打开，以及碳-卤素和碳-碳键的形成。 该方法的成功开发将对学术界和工业界的合成产生影响，特别是在组合催化和制药工艺领域。