Anhydrous Fluoride Salts

无水氟化盐

• 批准号: 0717562
• 负责人: Stephen DiMagno
• 金额: $ 42万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0717562&HistoricalAwards=false
• 关键词: Anhydrous; Fluoride; Salts

This project is focused on the development of environmentally-friendly techniques for generating anhydrous fluoride reagents, the elucidation of fundamental solution properties of anhydrous ammonium fluoride salts, and the demonstration of the utility of these reagents in synthetic chemistry. A diverse collection of new anhydrous fluoride salts will be synthesized. Complementary computational, kinetic and synthetic studies of nucleophilic fluorination reactions featuring these new salts will be performed. This project should advance significantly the understanding of solution phase behavior of weak electrolytes and the design criteria to enhance the stability and nucleophilicity of these reagents. The project will provide new reagents and strategies for the rapid and selective late stage introduction of fluorine. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Stephen G. DiMagno of the Department of Chemistry at the University of Nebraska-Lincoln, and Professor Andrew S. Koch of St. Mary's College of Maryland. This research program develops new methodology to prepare fluorinated organic compounds rapidly and efficiently. Fluorinated organic compounds are critical components of drug formulations, agrochemicals, PET imaging agents, and advanced materials. Selective fluorination methods are also highly prized in the pharmaceutical and agricultural industries, where approximately one third of currently marketed products contain fluorinated organic compounds. The straightforward nature and safety of fluorinating reagents and methods developed under this award make it possible for undergraduate researchers to make direct and significant contributions to technologically relevant research.

该项目的重点是开发用于生成无水氟化物试剂的环保技术，阐明无水氟化铵盐的基本溶液性质，以及演示这些试剂在合成化学中的效用。 将合成多种新型无水氟化物盐。 将对这些新盐的亲核氟化反应进行补充计算、动力学和合成研究。 该项目将显着促进对弱电解质溶液相行为的理解以及增强这些试剂的稳定性和亲核性的设计标准。 该项目将为快速、选择性的后期引入氟提供新的试剂和策略。有机与高分子化学项目通过该奖项支持内布拉斯加大学林肯分校化学系的 Stephen G. DiMagno 教授和马里兰州圣玛丽学院的 Andrew S. Koch 教授的研究。 该研究项目开发了快速有效制备氟化有机化合物的新方法。 氟化有机化合物是药物配方、农用化学品、PET 显像剂和先进材料的关键成分。选择性氟化方法在制药和农业行业也受到高度重视，目前市场上大约三分之一的产品含有氟化有机化合物。该奖项开发的氟化试剂和方法的简单性和安全性使本科生研究人员能够为技术相关研究做出直接和重大的贡献。