Improving the Sequence of the Maize Genome

改进玉米基因组的序列

• 批准号: 0910642
• 负责人: Richard Wilson
• 金额: $ 153.89万
• 依托单位: Washington University School of Medicine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0910642&HistoricalAwards=false
• 关键词: Improving; Sequence; Maize; Genome; Improving; Sequence; Maize; Genome

Maize is an important biological research system with a long and rich history. Over the past century, an active research community has grown up around the available extensive genetic tools and diverse germplasm. In this time, maize has become a leading system for addressing fundamental questions in genetics such as the impact of domestication on genome structure, the molecular basis of heterosis (hybrid vigor), and role of transposons in genome evolution. Research on maize has led to major advances in our understanding of fundamental life processes in plants such as reproduction, seed formation, germination, photosynthesis, and biosynthesis of primary metabolites including amino acids, carbohydrates and fatty acids. A genome sequence is a logical next step to enable the best use of maize as an experimental system and in order to translate research advances into improved crops. A draft sequence of the maize genome was generated, funded as part of the Maize Genome Sequencing Project: An NSF/DOE/USDA Joint Program, and released in February 2008. This project seeks to provide additional analysis and annotation information and provide the research community with a continuous, annotated reference genome sequence for maize. The specific aims of the project are to: 1) sequence and finish 500 fosmid clones; 2) produce an eight-fold (8X) whole genome shotgun sequence using a 454 platform; and 2) increase the scope of the genome assembly, analysis and annotation. The early impact of the current version of the maize genome sequence has been considerable. This project will provide the additional information and annotation to the reference sequence that will enable continued use of maize as an experimental system for advancing fundamental biology as well as the development of new and improved maize varieties in the public and private sector. Project information and data will be available through a web site accessible through the Washington University Genome Sequencing Center (http://www.genome.wustl.edu). Maize sequence assemblies and maize genetic resources will be incorporated into Gramene (http://www.gramene.org) and MaizeGDB (http://www.maizegdb.org).

玉米是一个重要的生物学研究系统，具有悠久而悠久的历史。在过去的一个世纪中，一个活跃的研究界已经围绕可用的广泛遗传工具和多样化的种质成长。在这段时间里，玉米已成为解决遗传学基本问题的领先系统，例如驯化对基因组结构的影响，杂种分子基础（杂种活力）以及转座子在基因组进化中的作用。对玉米的研究导致了我们对植物中基本生命过程的理解，例如繁殖，种子形成，发芽，光合作用，以及原代代谢产物（包括氨基酸，碳水化合物和脂肪酸）的生物合成。基因组序列是逻辑下一步，可以使玉米作为实验系统的最佳用途，并将研究进展转化为改进的作物。 生成了玉米基因组的草稿序列，作为玉米基因组测序项目的一部分资助：NSF/DOE/USDA联合计划，并于2008年2月发布。该项目旨在提供其他分析和注释信息，并为研究社区提供持续的，注释的注释参考基因组的玉米序列。 该项目的具体目的是：1）序列和完成500个Fosmid克隆； 2）使用454个平台生产一个八倍（8倍）整个基因组shot弹枪序列； 2）增加基因组组装，分析和注释的范围。 当前版本的玉米基因组序列的早期影响是相当大的。 该项目将为参考顺序提供其他信息和注释，这将使玉米继续使用玉米作为一个实验系统，以推进基本生物学以及开发公共和私营部门的新玉米品种。 项目信息和数据将通过华盛顿大学基因组测序中心（http://www.genome.wustl.edu）访问的网站获得。玉米序列组件和玉米遗传资源将纳入Gramene（http://www.gramene.org）和玉米（http://www.maizegdb.org）中。