Collaborative Research: MPSA-ENG: Interplay of Biosensing and Locomotion in Confined Microfluidic Environments

合作研究：MPSA-ENG：受限微流体环境中生物传感和运动的相互作用

• 批准号: 0852753
• 负责人: Amy Shen
• 金额: $ 24万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0852753&HistoricalAwards=false
• 关键词: Collaborative; Research; MPSA; ENG; Interplay

The proposal utilizes an interdisciplinary approach to study the locomotion of C. elegans and their sensory response to environmental variations. C. elegans is one of the mostly studied model animals in biology due to its genetic tractability, sequenced genome, simple anatomy and body transparency. It is also a superb system to study mobility and sensing. This project will use C. elegans as a simple model system of living organisms to obtain critical physical information for understanding the interplay between sensing, locomotion and environment, incorporate this information into theoretical and computational models of undulatory locomotion. This is a collaborative research project between a mechanical engineer at Washington University and a mathematical at the New York University.This research is expected to impact on smart sensing and actuation technology, and the results will serve as building blocks for development of smart devices that can lead to robust design of adaptive systems and structures.

该提案利用跨学科的方法研究秀丽隐杆线虫的运动及其对环境变化的感觉反应。秀丽隐杆线虫是生物学中主要研究的模型动物之一，因为其遗传性障碍性，测序的基因组，简单的解剖结构和身体透明度。它也是研究移动性和感知的出色系统。该项目将使用秀丽隐杆线虫作为一种简单的生物模型系统，以获取关键的物理信息，以理解感应，运动和环境之间的相互作用，将这些信息纳入不发光运动的理论和计算模型中。这是华盛顿大学的机械工程师与纽约大学的数学工程师之间的合作研究项目。这项研究有望影响智能传感和驱动技术，结果将是开发智能设备的基础，这些设备可以导致适应性的自适应系统和结构的强大设计。