CAREER: Synthesis, Characterization, and Applications of Cyclic Polymer "Nanoloops"

职业：环状聚合物“Nanoloops”的合成、表征和应用

• 批准号: 0844662
• 负责人: Scott Grayson
• 金额: $ 47.5万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0844662&HistoricalAwards=false
• 关键词: CAREER; Synthesis; Characterization; Applications; Cyclic

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)TECHNICAL SUMMARY: By using a highly efficient reaction to couple a polymer chain?s head and tail, this research project provides a versatile route for preparing cyclic polymers. Because of a variety of synthetic and technical limitations of previous synthetic routes, many fundamental properties of cyclic polymers remain debated, and their potential applications remain under-explored. The developed cyclization approach is powerful in that it can afford high purity cyclic polymers, while also providing access to linear analogs with identical molecular weight distributions. As a result, the effect of the cyclic topology on the polymers physical properties will be probed in a variety of studies, including thermal behavior, rheometry, degradation behavior, small angle x-ray scattering, and antimicrobial activity. In addition, the functional group tolerance of the polymerization and cyclization chemistries enables access to a range of functional cyclic backbones which can be further modified by the attachment of linear or dendritic polymer side-chains. These hybrid structures are of particular interest because the modular synthesis enables control over the size, rigidity, and functionality of the cyclic polymers. Their physical properties and their ability to encapsulate nanomaterials such as buckballs, quantum dots, and single walled nanotubes will be probed as a function of these variables. The overarching goal of this research is to obtain a better fundamental understanding of how the cyclic polymer architecture effects the interactions and physical properties of this family of macromolecules.NONTECHNICAL SUMMARY: Cyclic macromolecules, including plasmid DNA and many biologically relevant peptides, are well known in nature and exhibit unique properties and interactions as a result of their circular topology. However, the ability to efficiently prepare synthetic polymer ?nanoloops? has lagged significantly relative to the advanced synthetic control demonstrate for linear polymers. Using an efficient ?head-to-tail? coupling technique, high purity cyclic polymers can be obtained to probe the fundamental nature and potentially useful properties of these synthetic macromolecules. Of particular interest, cyclic molecules have been known to efficiently encapsulate smaller guest molecules, and these interactions will be explored for eventual materials and drug delivery applications. The technical nature of the described project will provide an exceptional, interdisciplinary training experience in both polymer synthesis and characterization for a diverse set of undergraduate and graduate students to help provide a well-trained body of researchers to address future materials needs. A very successful polymer-themed outreach program between Tulane researchers and predominantly underprivileged students at local New Orleans public schools will be continued under this award, to infuse the next generation of scientists with access to, interaction with, and inspiration from modern materials research.

该奖项是根据2009年《美国回收与再投资法》（公法111-5）的技术摘要进行资金的：通过使用高效的反应来将聚合物链的头部和尾巴夫妇伴随，该研究项目为准备环状聚合物提供了多功能途径。 由于以前的合成途径有各种综合和技术局限性，因此循环聚合物的许多基本特性仍在争论中，并且它们的潜在应用仍未得到探索。 开发的环化方法的功能强大，因为它可以负担得起高纯度环状聚合物，同时还可以访问具有相同分子量分布的线性类似物。 结果，将在各种研究中探测环状拓扑对聚合物物理特性的影响，包括热行为，流变测定，降解行为，小角度X射线散射和抗菌活性。 另外，聚合和环化化学的功能群耐受性可以访问一系列功能性循环骨架，可以通过线性或树突状聚合物侧链的附着来进一步修改它们。 这些杂交结构特别有趣，因为模块化合成可以控制环状聚合物的大小，刚度和功能。 它们的物理特性及其封装纳米材料的能力，例如雄鹿，量子点和单壁纳米管，将作为这些变量的函数进行探测。 这项研究的总体目的是获得对环状聚合物架构如何影响这种大分子家族的相互作用和物理特性的更好的基本了解。非技术性摘要：环状大分子，包括质粒DNA，包括许多生物学相关的肽，在自然和互动中是众所周知的独特属性，它们是独特的典型属性。 但是，有效制备合成聚合物的能力？相对于高级合成控制，线性聚合物的表现显着滞后。 使用高效？从头到尾？可以获得高纯度环状聚合物的耦合技术，以探测这些合成大分子的基本性质和潜在有用的特性。 特别有趣的是，已知环状分子有效地封装了较小的客体分子，这些相互作用将用于最终的材料和药物输送应用。 所描述的项目的技术性质将为各种本科生和研究生提供聚合物合成和表征的特殊，跨学科的培训经验，以帮助提供训练有素的研究人员，以满足未来的材料需求。 杜兰研究人员和主要是新奥尔良公立学校的主要贫困学生之间的非常成功的聚合物主题外展计划将继续遵守该奖项，以从现代材料研究中访问，与现代材料研究的互动和互动并获得互动和灵感。