Acquisition of a Cyber-Enabled 600 MHz NMR Spectrometer for Research and Teaching

采购一台支持网络的 600 MHz NMR 波谱仪用于研究和教学

• 批准号: 0840413
• 负责人: David Coleman
• 金额: $ 50万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0840413&HistoricalAwards=false
• 关键词: Acquisition; Cyber; Enabled; 600; MHz

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With support from the Chemistry Research Instrumentation and Facilities:Multiuser program (CRIF:MU), the Department of Chemistry at Wayne State University (WSU) will acquire a cyber-enabled 600 MHz nuclear magnetic resonance (NMR) spectrometer. It will be employed in research projects that span many areas of chemistry including (a) the chemistry of magnetic resonance imaging (MRI) and asymmetric catalysis; (b) the development of synthetic carbohydrate-based vaccines using zwitterionic polysaccharides (ZPSs); (c) the development of new, general methods for facile construction of six-membered and medium-sized ring systems (carbocycles and heterocycles); (d) applications to total synthesis of a wide variety of biologically active, structurally challenging natural products; (e) the development of new strategies for the synthesis of complex oligosaccharides and glycoconjugates; and (f) total synthesis of pharmacologically active natural products.Multinuclear NMR spectroscopy is an essential analytical tool in synthetic chemistry. NMR spectra enable researchers to identify their reaction products including unexpected substances and impurities. They reveal information on the connectivity of the atoms in molecules and materials - i.e. their structures - by detecting transitions between energy levels arising from the nuclear spin properties of atoms. The instrument will have an important and broad-based impact on WSU education and training mission. It will be used to support research projects of undergraduates, graduate students, and postdoctoral researchers, including traditionally underrepresented groups (that make up ca. 25% of the enrollment at WSU) as well at smaller nearby colleges and universities.

该奖项由 2009 年美国复苏和再投资法案（公法 111-5）资助。在化学研究仪器和设施：多用户计划 (CRIF:MU)、韦恩州立大学 (WSU) 化学系的支持下将购买一台具有网络功能的 600 MHz 核磁共振 (NMR) 波谱仪。 它将用于跨越许多化学领域的研究项目，包括（a）磁共振成像（MRI）化学和不对称催化； (b) 使用两性离子多糖（ZPS）开发基于碳水化合物的合成疫苗； (c) 开发新的通用方法以方便构建六元和中型环系统（碳环和杂环）； (d) 在全合成各种具有生物活性、结构上具有挑战性的天然产物中的应用； (e) 制定合成复杂寡糖和复合糖的新策略； (f)具有药理活性的天然产物的全合成。多核核磁共振波谱是合成化学中重要的分析工具。 核磁共振谱使研究人员能够识别其反应产物，包括意想不到的物质和杂质。 它们通过检测原子核自旋特性引起的能级之间的跃迁来揭示分子和材料中原子连接性的信息（即它们的结构）。 该工具将对华盛顿州立大学的教育和培训使命产生重要且广泛的影响。它将用于支持本科生、研究生和博士后研究人员的研究项目，包括传统上代表性不足的群体（约占 WSU 入学人数的 25%）以及附近规模较小的学院和大学。