CRIF: MU - Acquisition of a Cyber-Enabled Matrix Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometer

CRIF：MU - 采购网络支持的基质辅助激光解吸/电离 (MALDI) 质谱仪

• 批准号: 0840273
• 负责人: Lynn Penn
• 金额: $ 24.98万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0840273&HistoricalAwards=false
• 关键词: CRIF; MU; Acquisition; Cyber; Enabled

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), Lynn S. Penn and colleagues Haifeng Ji, Kevin G. Owens, Yen Wei, and Jun Zi from Drexel University will acquire a acquire a cyber-enabled matrix assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI/TOF) with post source decay (PSD) capabilities to provide accurate determinations of molecular weight distribution and average molecular weights of large, nonvolatile molecules, and to accomplish peptide analyses. The instrument will be used for understanding size selection criteria by which polymer brushes act as selective barriers to diffusion, synthesis of monodisperse electroactive polyanilines, synthesis and study of dendrons of controlled size, identification and characterization of the specific chemical sites involved in complexation of selected proteins, synthesis of polyelectrolytes for use in layer-bylayer formation of ultra-thin films, and synthesis of designed copolymers for creation of controlled two-phase microstructures on carbon nanotubes.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules and polymers. This research will have a significant impact in a number of areas, especially chemistry, materials and biochemistry. This instrument will be an integral part of teaching as well as research.

该奖项是根据2009年《美国回收与再投资法》（公法111-5）资助的。与化学研究工具和设施的奖项：Multiuser计划（CRIF：MU），Lynn S. Penn及其同事Haifeng JI，Kevin，Kevin Drexel University的G. Owens，Yen Wei和Jun Zi将获得获得网络支持的矩阵辅助激光解吸/电离飞行时间质谱仪（MALDI/TOF），并具有后源衰减（PSD）功能，以提供准确的功能测定大的非挥发分子的分子量分布和平均分子量，并完成肽分析。该仪器将用于理解尺寸选择标准，通过该标准，聚合物刷作为扩散的选择性障碍，单分散性电活性聚苯胺的合成，合成和对受控尺寸的树突的合成和研究，多电解质的合成用于超薄膜的层隔层形成，并合成设计的共聚物，用于在碳纳米管上创建受控的两相微结构。Malaldi-TOF-TOF-TOF-MASS光谱仪是获得准确的精确分子体重的技术在非常大的分子上，灵敏度极高。因此，使用MALDI-TOF质谱仪已成为一种标准技术，尤其是在涉及生物分子和聚合物的研究中。这项研究将在许多领域，尤其是化学，材料和生物化学方面产生重大影响。该工具将是教学和研究的组成部分。