New Strategies for Improved Molecuarly Imprinted Polymers

改进分子印迹聚合物的新策略

• 批准号: 0828897
• 负责人: Ken Shimizu
• 金额: $ 25万
• 依托单位: University South Carolina Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0828897&HistoricalAwards=false
• 关键词: New; Strategies; Improved; Molecuarly; Imprinted

CBET-0828897ShimizuThis NSF award by the Chemical and Biological Separations program supports work by Professor Ken D. Shimizu at the University of South Carolina at Columbia to develop polymers with recognition properties for use in chromatography and sensing applications. The molecular imprinting approach will be utilized to quickly and efficiently prepare polymers with desired affinities and selectivities. However, the imprinting process is also a low fidelity process that generates binding sites with a wide range of structures, affinities, and selectivities. This binding site heterogeneity has hindered the wider adoption of molecularly imprinted materials. Three new molecular imprinting strategies have been developed to specifically address the problem of binding site heterogeneity in imprinted polymers. These are: 1) development of multifunctional monomers, 2) site-specific post-modification strategies, and 3) template activated monomers. An advantage of these new strategies is that they can be used in tandem to optimize and tailor the binding properties of the polymers for specific applications. To demonstrate the utility of these new methods, imprinted polymers will be developed for use in an enantiomeric excess (ee) assay and for use as a chiral separation support in a HPLC column. The broader impacts of the proposed research will be development of methods to rapidly and inexpensively prepare polymers with tailored recognition properties. The improved binding properties of the imprinted materials will be widely applicable in analytical and biotechnical applications. These include catalysis, sensing, solid-phase extraction, drug delivery, and chromatography. The students working on this project will receive a highly multidisciplinary education, preparing them for research careers in polymer, pharmaceutical, and analytical chemistries. The award will also assist in supporting two outreach activities. The first is an outreach program for K-12 schools. The students are give chemical demonstrations in the areas schools with a focus on schools with a predominantly minority population. The second educational program is the development of a hands-on laboratory experience for high school students. The program brings high school classes to the University of South Carolina for a day. A molecular imprinted polymer laboratory has been designed, which exposes the students to cutting edge research. Additional interactive activities and tours are incorporated to introduce them to the scientific research environment.

CBET-0828897SHIMIZUTHIS NSF颁发的化学和生物学分离计划支持哥伦比亚南卡罗来纳大学的Ken D. Shimizu教授的工作，以开发具有识别属性的聚合物，以用于色谱和感应应用。分子烙印方法将用于快速有效地制备具有所需亲和力和选择性的聚合物。但是，印迹过程也是一个低忠诚过程，它会生成具有广泛结构，亲和力和选择性的结合位点。这种结合位点的异质性阻碍了更广泛的分子烙印材料的采用。已经制定了三种新的分子烙印策略，以特别解决印迹聚合物中结合位点异质性的问题。这些是：1）多功能单体的发展，2）特定于现场的后修饰策略和3）模板激活的单体。这些新策略的一个优点是，它们可以同时使用它们来优化和量身定制聚合物的结合特性，以用于特定应用。为了证明这些新方法的实用性，将开发印迹聚合物用于对映体过量（EE）测定法，并用作HPLC列中的手性分离支持。拟议的研究的更广泛的影响将是开发具有量身定制识别特性的聚合物的方法，以迅速和廉价地制备聚合物。印迹材料的改善结合特性将广泛适用于分析和生物技术应用。这些包括催化，传感，固相提取，药物递送和色谱法。从事该项目的学生将接受高度多学科的教育，为聚合物，药物和分析化学的研究职业做好准备。该奖项还将协助支持两项外展活动。首先是针对K-12学校的外展计划。学生们在学校的学校进行化学示威，重点是少数人口的学校。第二个教育计划是为高中生开发动手实验室经验。该计划将高中课带到南卡罗来纳大学一天。已经设计了一个分子印迹聚合物实验室，该实验室使学生接受了尖端研究。还进行了其他互动活动和游览，以将其介绍给科学研究环境。