Conformationally Programmable Molecular Receptors

构象可编程分子受体

• 批准号: 0616442
• 负责人: Ken Shimizu
• 金额: $ 42万
• 依托单位: University South Carolina Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616442&HistoricalAwards=false
• 关键词: Conformationally; Programmable; Molecular; Receptors

This project seeks to develop a new line of reprogrammable molecular receptors, in which recognition abilities could be reversibly written, saved, and erased. This is in contrast to the static nature of most synthetic molecules in which the molecular properties can only be set during its synthesis. This ability to alter and change recognition properties is accomplished using molecules that can adopt multiple room temperature stable conformations due to restricted rotation about C-N bonds. The molecules can be annealed in the presence of a guest to form complementary structures. These can then be saved as stable conformers by cooling to room temperature. Saved conformations can be erased by heating in the absence of guest or rewritten by heating with a different guest. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Ken D. Shimizu of the Department of Chemistry at University South Carolina Research Foundation. Professor Shimizu's research efforts revolve around the development of recognition materials that are multifunctional due to dynamic control over their molecular properties. The proposed strategy could be extended to other conformationally dependent properties, such as solubility, viscosity, and refractive index. The proposed mechanism also shares many similarities with dynamic biological processes such as protein folding and could serve as models for these.

该项目旨在开发一种新的可重编程分子受体，其中可以可逆地写，保存和擦除识别能力。 这与大多数合成分子的静态性质形成鲜明对比，其中只能在其合成过程中设置分子特性。 这种更改和改变识别属性的能力是使用分子来实现的，该分子由于围绕C-N键的旋转而产生多个室温稳定构象。 可以在客人存在的情况下退火分子以形成互补结构。 然后，可以通过冷却至室温将其保存为稳定的构象异构体。 在没有客人的情况下加热可以消除保存的构象，或与其他客人一起加热。 通过该奖项，有机和大分子化学计划正在支持南卡罗来纳州大学研究基金会化学系的Ken D. Shimizu教授的研究。 Shimizu教授的研究工作围绕着由于对其分子特性的动态控制而导致多功能的识别材料的发展。 提出的策略可以扩展到其他构型依赖性特性，例如溶解度，粘度和折射率。 所提出的机制还与动态生物学过程（例如蛋白质折叠）共享许多相似之处，并且可以作为这些模型。