Deuterostome Endomesoderm Specification: Insights from Hemichordates

后口动物内中胚层规格：来自半索动物的见解

• 批准号: 0818679
• 负责人: Christopher Lowe
• 金额: $ 54万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0818679&HistoricalAwards=false
• 关键词: Deuterostome; Endomesoderm; Specification; Insights; Hemichordates

Introduction: The evolutionary origins of our own phylum, the chordates, have been a topic of intense debate for the past 200 years. Despite broad interest in the issue, little consensus has emerged from this intense research scrutiny. Recent advances in our understanding of the relationships between the groups of animals closely related to chordates, and the technological advances from molecular genetics, make this key issue much more experimentally tractable. This work investigates the developmental biology of a phylum called hemichordates, which is one of the most closely related groups to chordates. Approach: This project examines how the mesoderm and endoderm are set up in this phylum. The mesoderm is a tissue layer that gives rise to many of the key innovations of our own phylum such as skeleton and the associated complex musculature. The endoderm gives rise to our complex gut and associated glands. Expected results: Investigating the role of genes with conserved roles in inducing and patterning chordate endoderm and mesoderm will help reconstruct the early evolution of these tissue layers and how they were modified and diversified to produce the critical morphological structures that define our phylum. A comparative study of the gene networks involved in endoderm and mesoderm development will give additional insights into how they function in vertebrates. Broader impacts: This project will involve the training and participation of undergraduate and graduate students at the University of Chicago. The PI and graduate students will present the results at a broad range of institutions and internally conferences.

简介：在过去的200年中，我们自己的门的进化起源，弦核，一直是激烈辩论的话题。尽管对这个问题有广泛的兴趣，但这种严格的研究审查几乎没有达成共识。我们对与弦核密切相关的动物群体之间关系以及分子遗传学的技术进步的最新进展，使这一关键问题在实验上更具实验性。这项工作调查了一个名为Hemichordates的门的发育生物学，该生物学是与和弦最密切相关的群体之一。方法：该项目研究了中胚层和内胚层是如何在此门中设置的。中胚层是一个组织层，可产生我们自己的门（例如骨骼和相关复合肌肉组织）的许多关键创新。内胚层产生了我们复杂的肠道和相关的腺体。预期结果：研究具有保守作用的基因在诱导和构图脊柱内胚层和中胚层中的作用将有助于重建这些组织层的早期演变，以及如何修饰和多样化，以产生定义我们的门的关键形态结构。对内胚层和中胚层发育中涉及的基因网络的比较研究将为它们在脊椎动物中的功能提供更多见解。更广泛的影响：该项目将涉及芝加哥大学本科生和研究生的培训和参与。 PI和研究生将在广泛的机构和内部会议上展示结果。