Starter Grant: Molecular Analysis of Regulation of Methane gene Transcription in the Archaeon Methanothermobacter Thermoautotrophicus

启动资金：古细菌嗜热甲烷杆菌热自养甲烷基因转录调控的分子分析

• 批准号: 0803286
• 负责人: Elizabeth Karr
• 金额: $ 5万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0803286&HistoricalAwards=false
• 关键词: Starter; Grant; Molecular; Analysis; Regulation

The goal of this project is to gain a molecular-level understanding of the regulation of methane gene expression in Archaea. A range of in vitro molecular techniques will be used to comprehensively characterize two regulators of methane gene transcription in Methanothermobacter thermautotrophicu. This research will help establish how methanogenesis is regulated, and the dissection of the regulatory mechanics will substantially extend knowledge of transcription regulation in Archaea. Methanogenesis is a metabolism of global environmental and economic importance and the results obtained will add insight into the regulation of methane generation.This project will contribute to the career development of an underrepresented minority investigator through establishment of her research program at the University of Oklahoma. Research opportunities will be provided for a graduate student and one undergraduate in molecular microbiology, anaerobic microbiology, and biochemistry.

该项目的目标是在分子水平上了解古细菌中甲烷基因表达的调控。 将使用一系列体外分子技术来全面表征嗜热甲烷杆菌中甲烷基因转录的两个调节因子。这项研究将有助于确定产甲烷作用是如何调节的，对调节机制的剖析将大大扩展古细菌转录调节的知识。 产甲烷作用是一种对全球环境和经济具有重要意义的新陈代谢，所获得的结果将增加对甲烷生成调节的深入了解。该项目将通过在俄克拉荷马大学建立她的研究项目，为一名代表性不足的少数族裔研究员的职业发展做出贡献。将为一名研究生和一名本科生提供分子微生物学、厌氧微生物学和生物化学方面的研究机会。