Effects of an oral supplementation of arginine, citrulline and glutamine on the development and progression of non-alcoholic fatty liver disease (NAFLD): Role of gender and age

口服补充精氨酸、瓜氨酸和谷氨酰胺对非酒精性脂肪肝 (NAFLD) 发生和进展的影响：性别和年龄的作用

基本信息

批准号：
183849079
负责人：
Professorin Dr. Ina Bergheim
金额：
--
依托单位：
Department für Ernährungswissenschaften
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2010
资助国家：
德国
起止时间：
2009-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/183849079?language=en
关键词：
Effects oral supplementation arginine citrulline

项目摘要

The prevalence of non-alcoholic fatty liver disease (NAFLD) hasmarkedly increased and by now NAFLD is one of the most frequentliver diseases worldwide; however, universally accepted, successfultherapies are still lacking. Studies indicate that even early stages ofNAFLD are associated with an increased intestinal translocation ofbacterial endotoxin in the intestine and an induction of toll-likereceptor (TLR)-dependent signaling pathways in the liver. Results ofthe first funding period using animal models suggest that an oralsupplementation of arginine, citrulline or glutamine possess protectiveeffects on the development of NAFLD. Our data further suggest thatthe mechanisms involved herein markedly differ between the threeamino acids. If an oral supplementation of the amino acids alsopossess therapeutic effects on the progression of NAFLD has not yetbeen clarified. Therefore, the aim of the present research project is (1)to further delineate the mechanisms involved in the protective effectsof arginine, citrulline and glutamine on the development of NAFLD inmice with a special focus on changes in hepatic fatty acid distributionand intestinal microbiota and (2) to determine if the three amino acidsalso possess therapeutic effects on the disease in mice thereby alsoaiming to add to the development of new prevention and therapeuticstrategies.

非酒精性脂肪肝疾病（NAFLD）的患病率已经增加了，到现在为止，NAFLD是全球最常见的疾病之一。但是，仍然缺乏普遍接受，成功的行动。研究表明，即使是NAFLD的早期阶段也与肠内细菌内毒素的肠道易位增加以及肝脏中依赖性依赖性信号感受器（TLR）依赖性信号通路的诱导有关。使用动物模型的第一个融资期的结果表明，精氨酸，瓜氨酸或谷氨酰胺的口服支持对NAFLD的发展具有保护作用。我们的数据进一步表明，此处涉及的机制在threeamino酸之间明显不同。如果对氨基酸的口服补充对NAFLD进展的治疗作用尚未阐明。因此，本研究项目的目的是（1）进一步描述精氨酸，瓜氨酸和谷氨酰胺对NAFLD INMICE开发的保护作用的机制，并特别关注肝脂肪酸分布的变化和肠道肠道菌群和2（2 ）确定三种氨基酸对小鼠的疾病是否具有治疗作用，从而增加了新的预防和治疗策略的发展。