MRI: Acquisition of a Confocal Microscope

MRI：购买共焦显微镜

• 批准号: 0722569
• 负责人: Daphne Blumberg
• 金额: --
• 依托单位: University of Maryland Baltimore County
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0722569&HistoricalAwards=false
• 关键词: MRI; Acquisition; Confocal; Microscope

This award is for the acquisition of a confocal microscope with: a conventional scan head for high resolution scanning, visible wave length lasers, and acousto optical tunable filters and beam splitters for precise wavelength control of excitation and emission allowing for the use of a wide variety of fluors for colocalization studies and for live cell imaging. Research projects needing the microscope include: investigating the mechanisms of cell differentiation; studying transcription regulation and receptor trafficking; and investigating protein aggregation, cell adhesion, cytoskeletal reorganization, odorant sensing and plant defense systems. The applications range from tissue engineering and biomaterials, to the development of nanosensors and the investigation of molecular and cellular level phenomena, all aimed at solving a variety of problems of societal importance. The microscope will support the research and teaching needs of a relatively new research university campus with an outstanding record of mentoring women and minorities in the sciences and engineering at all levels. This record is reflected in the composition of the user group involved with this award. Ten of the fifteen labs that comprise the user group are headed by women investigators, including an African-American and a Hispanic. They include a PECASE awardee and a Clair Booth Luce Fellow. In addition to undergrads from the university, undergrads using the microscope will come through summer programs for undergrads from Historically Black Colleges, Community Colleges, and non-research colleges.

该奖项授予共焦显微镜，该显微镜具有：用于高分辨率扫描的传统扫描头、可见波长激光器、声光可调滤光片和分束器，用于精确控制激发和发射的波长，从而允许使用各种用于共定位研究和活细胞成像的荧光体。需要显微镜的研究项目包括：研究细胞分化的机制；研究转录调控和受体运输；并研究蛋白质聚集、细胞粘附、细胞骨架重组、气味传感和植物防御系统。应用范围从组织工程和生物材料，到纳米传感器的开发以及分子和细胞水平现象的研究，所有这些都旨在解决各种具有社会重要性的问题。该显微镜将支持相对较新的研究型大学校园的研究和教学需求，该大学校园在各级科学和工程领域为女性和少数族裔提供指导方面有着出色的记录。这一记录体现在参与该奖项的用户群体构成中。组成用户组的十五个实验室中有十个由女性调查员领导，其中包括一名非裔美国人和一名西班牙裔美国人。他们包括一名 PECASE 获奖者和一名 Clair Booth Luce 研究员。 除了大学的本科生之外，使用显微镜的本科生还将参加历史黑人学院、社区学院和非研究型学院的本科生暑期课程。