NIRT: Self-Assembled Nanohydrogels for Differential Cell Adhesion and Infection Control

NIRT：用于差异细胞粘附和感染控制的自组装纳米水凝胶

• 批准号: 0708379
• 负责人: Matthew Libera
• 金额: $ 100万
• 依托单位: Stevens Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0708379&HistoricalAwards=false
• 关键词: NIRT; Self; Assembled; Nanohydrogels; Differential

This proposal was received in response to the Active Nanostructures and Nanosystems initiative, NSF 06-595, category NIRT. CBET-0708379Libera, Matthew R.Stevens Institute of TechnologyTitle:NIRT: Self-Assembled Nanohydrogels for Differential Cell Adhesion and Infection ControlThis project centers on the design and self-assembly of nanohydrogels that will either be adhesive to cells or repulsive to cells.The special adhesive feature of the biomaterial relies on the detailed spatial composition of cell-adhesive and cell-repulsive nano sized hydrogels. The investigators are utilizing the well-documented differential in binding of eukaryotic cells versus bacteria. They are utilizing a very straight forward and creative mechanism for creating these controllable cell adherent surfaces. Finally, the successful completion of the project will lead to a major advancement in biomaterial. Such material will find wide surgical application.

该提案是为了响应活性纳米结构和纳米系统倡议（NSF 06-595，NIRT 类别）而收到的。 CBET-0708379Libera，马修·R·史蒂文斯理工学院标题：NIRT：用于差异细胞粘附和感染控制的自组装纳米水凝胶该项目集中于纳米水凝胶的设计和自组装，这些纳米水凝胶要么粘附于细胞，要么排斥细胞。生物材料的粘附特性依赖于细胞粘附和细胞排斥纳米尺寸水凝胶的详细空间组成。 研究人员正在利用有据可查的真核细胞与细菌结合的差异。他们正在利用一种非常直接和创造性的机制来创建这些可控的细胞粘附表面。最后，该项目的成功完成将带来生物材料领域的重大进步。这种材料将得到广泛的外科应用。