U.S.-Egypt Cooperative Research: Improving Healing Performance of Wound Dressings through Formation of High Surface Area Chitosan/Cellulose Structures From Electrospun Nanofibers

美国-埃及合作研究：通过静电纺纳米纤维形成高表面积壳聚糖/纤维素结构来提高伤口敷料的愈合性能

• 批准号: 0709654
• 负责人: Abdelfattah Seyam
• 金额: --
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0709654&HistoricalAwards=false
• 关键词: U.S.; Egypt; Cooperative; Research; Improving

0709654SeyamDescription: This project supports collaborative research by Dr. Abdelfattah Seyam, Department of Textile and Apparel Technology, North Carolina State University, Raleigh, North Carolina. The collaborating scientist is Dr. Ahmad Waly, National Research Center, Cairo, Egypt. They plan to study how to improve the healing performance of wound dressing through formation of high surface area chitosan/cellulose structures from electrospun nanofibers Intellectual Merit: The collaborators will conduct fundamental research to develop and evaluate highly absorbable inexpensive chitosan/cellulose based structures with high surface area using electrospun nanofibers. The main goal is to form and evaluate composite structures for wound dressings. The structures consist mainly of two components. The first is a cellulose based hydrogelled material capable of absorbing at least 10 times of its weight of wound discharge liquids. The hydrogel fibrous structures will be formed by grafting with a vinyl monomer to impart hydrophilic functional groups. The second is a nonwoven layer of nanofibers formed by electrospinning the nanofibers from chitosan/cellulose solutions. The PIs will form a range of extremely thin nonwovens from chitosan/cellulose nanofibers using different blend ratios, electric fields, solution concentrations, and process speeds and study the impact of these on the formed structures (fiber diameter and orientation, surface area, and pore size). The combined fibrous structures of hyrogelled and nanofibers nonwoven will be evaluated for healing performance. Contact kill performance of the structures against range of bacteria and yeast in static test (AATCC Method 100) and dynamic mode (ASTM E-2149-01) will be evaluated. The percent reduction of bacteria (number killed as a percent of total number) as a function of time will be monitored (Modified ASTM E-2149-01). These tests assess healing performance/time of the developed fibrous structures. The healing performance will be correlated to the structural parameters of the nanofibers and the hydrogilled layers, in order to design wound dressings to meet specific needs. Broader Impact: The results of this research should lead to design of wound dressings with predetermined structures and healing performance to fit specific needs. While the focus of this research is on wound dressing, the expected knowledge from such research will be helpful in developing inexpensive fibers for other applications such as hospital bed sheets, surgical gowns, and medical gloves. Two post-doctoral scientists and a graduate student from NCSU will be partially supported through this project. This project is being supported under the US-Egypt Joint Fund Program, which provides grants to scientists and engineers in both countries to carry out these cooperative activities.

0709654Seyam 描述：该项目支持北卡罗来纳州罗利市北卡罗来纳州立大学纺织和服装技术系 Abdelfattah Seyam 博士的合作研究。 合作科学家是埃及开罗国家研究中心的 Ahmad Waly 博士。 他们计划研究如何通过静电纺丝纳米纤维形成高表面积壳聚糖/纤维素结构来提高伤口敷料的愈合性能。使用静电纺丝纳米纤维的区域。主要目标是形成和评估伤口敷料的复合结构。 该结构主要由两个部分组成。第一种是基于纤维素的水凝胶材料，能够吸收至少10倍于其重量的伤口分泌物液体。水凝胶纤维结构将通过接枝乙烯基单体以赋予亲水官能团而形成。第二层是由壳聚糖/纤维素溶液静电纺丝纳米纤维形成的纳米纤维非织造层。 PI 将使用不同的混合比、电场、溶液浓度和加工速度，由壳聚糖/纤维素纳米纤维形成一系列极薄的非织造布，并研究这些对形成的结构（纤维直径和取向、表面积和孔隙）的影响。尺寸）。将评估水凝胶和纳米纤维非织造布的组合纤维结构的愈合性能。将评估静态测试（AATCC 方法 100）和动态模式（ASTM E-2149-01）中结构对各种细菌和酵母的接触杀灭性能。将监测作为时间函数的细菌减少百分比（杀死的数量占总数的百分比）（修改后的 ASTM E-2149-01）。这些测试评估已发育的纤维结构的愈合性能/时间。愈合性能将与纳米纤维和水镀层的结构参数相关，以便设计伤口敷料以满足特定需求。 更广泛的影响：这项研究的结果应该导致设计具有预定结构和愈合性能的伤口敷料，以满足特定需求。虽然这项研究的重点是伤口敷料，但此类研究的预期知识将有助于开发用于其他应用的廉价纤维，例如医院床单、手术服和医用手套。北卡罗来纳州立大学的两名博士后科学家和一名研究生将通过该项目获得部分支持。 该项目得到了美国-埃及联合基金计划的支持，该计划向两国的科学家和工程师提供赠款以开展这些合作活动。