U.S. Egypt Cooperative Research: Surface Modification and Size Dependence of Magnetic Nanoparticles for Biomedical Applications

美埃合作研究：用于生物医学应用的磁性纳米颗粒的表面改性和尺寸依赖性

• 批准号: 1004228
• 负责人: Chanjoong Kim
• 金额: $ 5万
• 依托单位: Kent State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1004228&HistoricalAwards=false
• 关键词: U.S.; Egypt; Cooperative; Research; Surface

This proposal is to investigate effects of size, shape and surface modification of magnetic nanoparticles (MNPs), which have been used in biomedical applications such as magnetic resonance imaging (MRI), tissue engineering, hyperthermia, and gene and drug delivery. The US PI will be collaborating with Dr. Emad Girgis at the National Research Centre (NRC) in Egypt.Intellectual Merit: In this project, the PIs will synthesize MNPs of different sizes and shapes and surface modification for in-vivo applications. The particle diameter and structure will be investigated using FESEM, TEM, and XRD analyses. The magnetic properties of the MNPs will be measured at room temperature using vibrating samples magnetometer. MNPs with a mean size of 5-10 nm will be prepared under inert atmosphere, with support of natural polymeric starch, by using chemical colloidal method. The surface of MNPs will be treated with a coordinatable agent for higher dispersion ability in water and retaining the superparamagnetic property. The prepared magnetic nanoparticles will be coated with starch, dextran, PEG, MPEG or polymerizable liposomes to extend their application potential in various fields of nano biomedicine. Before using the magnetic nanoparticles in biomedicine applications, we will investigate the genotoxicity of the MNPs to optimize the surface modification processes. Finding non- or minimal genotoxic MNPs is the final goal of this project. The results from this project will not only transform our understanding on the relationship between the genotoxicity and the surface modification on MNPs, but also provide pivotal guidelines in designing a new class of nanoparticles and coating materials for numerous biotechnology and biomedical applications. Broader Impact: A postdoctoral student will be actively engaged in project and will have an opportunity to travel to Egypt during the project for an international research experience. The PI intends to collaborate with industrial researchers and to publish research results will be published on his website (http://wilhelmy.lci.kent.edu) for broad access. The proposed research will be integrated in educational and outreach programs. At the graduate level, the US PI will accommodate the research methods and results in a new course offering at KSU. In this course, graduate students will gain a broad exposure to soft matter and biomaterials and will have ample opportunities to gain teaching experience in lab demonstrations. Outcomes resulting from this collaborative effort between the Egyptian and US teams may be useful for magnetic resonance imaging (MRI), gene and drug delivery applications.The project is funded under the US-Egypt Joint Fund Program, which provides grants to scientists and engineers in both countries to undertake cooperative research.

该建议是研究磁性纳米颗粒（MNP）的尺寸，形状和表面修饰的影响，这些影响已用于生物医学应用，例如磁共振成像（MRI），组织工程，高温和基因和药物递送。美国PI将与埃及国家研究中心（NRC）的EMAD GIRGIS博士合作。智能优点：在该项目中，PIS将合成不同尺寸和形状的MNP，以及用于体内应用的表面修饰。将使用FESEM，TEM和XRD分析研究颗粒直径和结构。 MNPS的磁性特性将在室温下使用振动样品磁力计测量。使用化学胶体方法，在惰性气氛下，在惰性气氛下将制备平均大小为5-10 nm的MNP。 MNP的表面将用可坐标剂处理，以使水中的较高分散能力并保留超磁特性。制备的磁性纳米颗粒将涂有淀粉，葡萄糖，钉，mpeg或可聚合脂质体，以扩展其在纳米生物医学各个领域的施用电位。在在生物医学应用中使用磁性纳米颗粒之前，我们将研究MNP的遗传毒性以优化表面​​修饰过程。寻找非遗传毒性MNP是该项目的最终目标。该项目的结果不仅会改变我们对MNP的遗传毒性和表面修饰之间关系的理解，而且还提供了设计新的纳米颗粒和涂料材料的关键指南，以供许多生物技术和生物医学应用。更广泛的影响：博士后生将积极参与项目，并有机会在该项目期间前往埃及进行国际研究经验。 PI打算与工业研究人员合作并发布研究结果，将在其网站（http://wilhelmy.lci.kent.edu）上发布，以供广泛访问。拟议的研究将纳入教育和外展计划。在研究生层面，美国PI将适应研究方法，并在KSU提供新的课程。在本课程中，研究生将广泛接触软件和生物材料，并有足够的机会在实验室示范中获得教学经验。埃及和美国团队之间的合作努力产生的成果可能对磁共振成像（MRI），基因和药物输送应用有用。