Evaluation of Bisphosphonate Containing Coated Ti Foams for Osteoporosis Treatment

含双膦酸盐涂层钛泡沫治疗骨质疏松症的评价

• 批准号: 0700306
• 负责人: Sarit Bhaduri
• 金额: --
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0700306&HistoricalAwards=false
• 关键词: Evaluation; Bisphosphonate; Containing; Coated; Ti

0700306BhaduriThe goal of this research is to develop surface engineered bisphoshonate (BP)-coated reticulated Ti foam scaffolds for the treatment of bone loss (such as osteoporosis). This objective is based on the effectiveness of BPs in preventing bone-loss, and as an alternative to the oral-administration of BPs to avoid side-effects while acting much more quickly. The proposed work builds upon the biomimetic coating of Ti foams with BP-loaded CDHA as it helps bone-loss treatments in a dual manner by increasing the bone-building osteoblasts and by causing apoptosis of bone-resorbing osteoclasts. This research will address the following objectives: (1) use the parameters obtained from the investigators previous research to produce crack-free BP-loaded coated flat substrates, (2) determine the chemical characteristics of the as-coated BP-loaded substrates, (3) based on the results, coat reticulated Ti foams, and (4) perform in vitro tests to examine both osteoclast and osteoblast response of the BP loaded substrates and foams. The local and selective delivery of drugs is seen as part of the future of medical treatments. Thus, the proposed work would contribute towards drug implant technology for the treatment of osteoporosis. The project will involve underrepresented undergraduate students and K-12 outreach.

0700306Bhaduri 这项研究的目标是开发表面工程双膦酸盐（BP）涂层的网状钛泡沫支架，用于治疗骨质流失（例如骨质疏松症）。这一目标基于 BP 在预防骨质流失方面的有效性，并且作为口服 BP 的替代方案，以避免副作用，同时起效更快。这项工作建立在钛泡沫仿生涂层的基础上，其上负载有 BP 的 CDHA，因为它通过增加骨形成成骨细胞和引起骨吸收破骨细胞凋亡，以双重方式帮助骨质流失治疗。 本研究将实现以下目标：（1）使用研究人员先前研究获得的参数来生产无裂纹的负载 BP 的涂层平坦基材，（2）确定涂层的负载 BP 基材的化学特性，（ 3) 根据结果，涂覆网状钛泡沫，并且 (4) 进行体外测试，以检查负载 BP 的基底和泡沫的破骨细胞和成骨细胞反应。局部选择性药物输送被视为未来医疗的一部分。因此，拟议的工作将有助于治疗骨质疏松症的药物植入技术。该项目将涉及代表性不足的本科生和 K-12 外展活动。