CAREER:Developing Novel Nuclear Magnetic Resonance Contrast and Sensitivity Enhancement Mechanisms for Materials and Reactions Studies

职业：开发用于材料和反应研究的新型核磁共振对比和灵敏度增强机制

• 批准号: 0645536
• 负责人: Song-I Han
• 金额: $ 73.39万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645536&HistoricalAwards=false
• 关键词: CAREER; Developing; Novel; Nuclear; Magnetic

Song-I Han of the University of California-Santa Barbara is supported by the Experimental Physical Chemistry Program to develop novel contrast mechanisms for nuclear magnetic resonance (NMR) that highlight molecule-specific functions of materials and processes by targeted signal enhancement of selected fluid molecules. Two different approaches for achieving non-equilibrium nuclear spin polarization will be pursued and developed, presenting mechanisms to obtain different types of contrast. One approach, utilizing inserted or natural unpaired electrons in solid matrices for NMR signal modulation, has not been demonstrated previously. In the research effort, (1) the widely used Overhauser effect will be extended to a broader range of nuclei and molecules, (2) a better understanding of the interactions between nuclei and unpaired electrons in materials will be achieved, (3) flow dispersion, absorption and reactivity of molecules in porous materials -- difficult properties to study-- will be accessed in situ, and (4) light will be shed on the whereabouts of active sites in heterogeneous catalysts. Theoretical efforts, instrumentation development utilizing emerging, high-power, microwave technology and the integration of interdisciplinary knowledge will be employed to meet the research aims.Novel contrast and higher sensitivity NMR as developed in this project will allow the exploitation of molecule-material interactions that are currently difficult to access. The developing capability to trace directly the transport and absorption of small molecules into porous media in situ is highly significant in a broad range of areas such as chemical reaction, biological function, drug delivery, and petroleum research. The educational project plan includes the organization of magnetic resonance based workshops and field studies for undergraduate and high school students that will give them the opportunity for hands-on learning about magnetic fields and how NMR can be used to learn about common materials in the environment.

加利福尼亚大学圣塔芭芭拉分校的Song-I Han得到了实验物理化学计划的支持，以开发用于核磁共振的新型对比机制（NMR），该机制通过靶向信号增强所选流体分子的靶向信号来突出材料和过程的分子特异性功能。将采用和开发两种不同的方法来实现非平衡核自旋极化，并提出获得不同类型的对比的机制。以前尚未证明一种使用固体矩阵中插入或天然未配对电子进行NMR信号调制的方法。 In the research effort, (1) the widely used Overhauser effect will be extended to a broader range of nuclei and molecules, (2) a better understanding of the interactions between nuclei and unpaired electrons in materials will be achieved, (3) flow dispersion, absorption and reactivity of molecules in porous materials -- difficult properties to study-- will be accessed in situ, and (4) light will be shed on the whereabouts of异质催化剂中的活性位点。理论上的努力，利用新兴，高功率，微波技术的仪器开发以及将采用跨学科知识的整合来满足研究目的。该项目中开发的Novel对比度和较高的敏感性NMR将允许利用目前难以访问的分子 - 物质交互。 在化学反应，生物功能，药物递送和石油研究等广泛的区域中，将小分子直接追踪和吸收到多孔培养基中的发展能力非常重要。教育项目计划包括针对本科和高中生的基于磁共振的研讨会和现场研究，这将为他们提供动手学习磁场的机会，以及如何使用NMR来学习环境中的常见材料。