ATOL: Collaborative Research: Resolving Mammalian Phylogeny with Genomic and Morphological Approaches

ATOL：合作研究：用基因组和形态学方法解决哺乳动物系统发育问题

• 批准号: 0629860
• 负责人: Mark Springer
• 金额: $ 80万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0629860&HistoricalAwards=false
• 关键词: ATOL; Collaborative; Research; Resolving; Mammalian

AToL: Collaborative Research: Resolving Mammalian Phylogeny with Genomic and Morphological ApproachesNovacek, Michael J., American Museum of Natural History, EF 0629811 Murphy, William J., Texas A & M Research Foundation, EF 0629849 O'Leary, Maureen A., SUNY Stony Brook, EF 0629836 Luo, Zhe-Xi, Carnegie Institute, EF 0629959 Springer, Mark, Univ. California, Riverside, EF 0629860 AbstractOnly a few of the myriad biological groups now thriving on this planet have fossil records that chronicle their evolutionary past. One of these few is Mammalia, known from about 5,000 extant species distributed among 1135 living genera, including our own human lineage, and more than 4,000 extinct genera, a four-to-one ratio of fossil genera to living genera that can hardly be matched elsewhere in the biota. Mammals display a spectacular range in size, form, and adaptations. They are closely linked to human health, welfare, and experience. No tree of all life could be regarded as complete without a comprehensive phylogeny of Mammalia. This conviction has inspired a surge of work in paleontology, comparative anatomy, and molecular biology. Despite these significant gains, many aspects of mammalian phylogeny are unresolved or highly controversial, even at some of the major branching points on the mammalian tree. PIs propose to examine species exemplars for 135 extant families, the majority of some 350 extinct families, and to extend this sample to a generic-level data set of 500 extant and nearly 500 extinct genera for combined analysis of genes and morphology. Their molecular team will continue to sample taxa toward a goal of covering 95% of all living genera outside the murids (rats, mice, and kin) and sciurids (squirrels). For character evidence, PIs plan to sample 30Kb in gene sequences from 34 genes for at least one exemplar of all living families. For the larger generic-level phases of the project, they will sample at least 6Kb of sequence. Morphologists will collect a projected 2,000 characters. Completion of a broad scale phylogeny for mammals will provide a model system in evolutionary and comparative biology with numerous applications in conservation and wildlife management, human health, biomedicine, and other areas. In addition, PIs intend to compile an integrated and image rich database for mammalian characters and convert it into a powerful toolkit for conservation management, education, and outreach through training programs and web resources.

AToL：合作研究：用基因组和形态学方法解决哺乳动物系统发育Novacek，Michael J.，美国自然历史博物馆，EF 0629811 Murphy，William J.，德克萨斯农工大学研究基金会，EF 0629849 O'Leary，Maureen A.，纽约州立大学石溪，EF 0629836 罗哲熙，卡内基研究所，EF 0629959 施普林格，马克，大学。加利福尼亚州河滨市 EF 0629860 摘要 在这个星球上繁衍生息的无数生物群体中，只有少数拥有记录其进化历史的化石记录。哺乳动物就是其中之一，已知的现存物种约有 5,000 种，分布在 1135 个现存属中，包括我们人类的谱系，以及 4,000 多个已灭绝的属，化石属与现存属的比例为四比一，难以匹敌。生物群的其他地方。 哺乳动物在体型、形态和适应性方面表现出惊人的变化范围。它们与人类的健康、福利和经验密切相关。如果没有全面的哺乳动物系统发育史，所有生命之树都不能被认为是完整的。这一信念激发了古生物学、比较解剖学和分子生物学领域的大量工作。尽管取得了这些重大进展，哺乳动物系统发育的许多方面仍未解决或极具争议，即使在哺乳动物树上的一些主要分支点也是如此。 PI 提议检查 135 个现存科（约 350 个已灭绝科中的大多数）的物种样本，并将该样本扩展到包含 500 个现存属和近 500 个已灭绝属的通用级数据集，以便对基因和形态进行组合分析。他们的分子团队将继续对分类群进行采样，目标是覆盖鼠科动物（大鼠、小鼠和近亲）和松鼠科动物（松鼠）之外的所有生物属的 95%。为了获得特征证据，PI 计划从所有现存家庭的至少一个样本的 34 个基因中抽取 30Kb 的基因序列样本。对于项目的较大通用级阶段，他们将采样至少 6Kb 的序列。 形态学家将收集预计 2,000 个字符。哺乳动物大规模系统发育的完成将为进化和比较生物学提供一个模型系统，在保护和野生动物管理、人类健康、生物医学和其他领域具有广泛的应用。此外，PI 打算编制一个完整的、图像丰富的哺乳动物特征数据库，并将其转化为一个强大的工具包，用于保护管理、教育和通过培训计划和网络资源进行推广。