CRC: Long-Range Electron Transfer in Hybrid Inorganic-Peptide Nucleic Acid Nanoscale Assemblies

CRC：混合无机肽核酸纳米级组装体中的长程电子转移

• 批准号: 0628169
• 负责人: Eric Borguet
• 金额: --
• 依托单位: Temple University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0628169&HistoricalAwards=false
• 关键词: CRC; Long; Range; Electron; Transfer

David H. Waldeck (University of Pittsburgh), Catalina Achim (Carnegie Mellon University), David N. Beratan (Duke University), Eric U. Borguet (Temple University) and Marcela Madrid (Pittsburgh Supercomputing Center) are jointly supported to study the electron transfer processes in peptide nucleic acid (PNA)-based structures. The team will study the properties of PNAs that contain paramagnetic transition metal ions in well-defined locations. The team will use experimental (i.e., spectroscopy, microscopy and electrochemistry) and theoretical (i.e., molecular dynamics simulations and quantum chemistry) methods to study the electron transport properties of these nanoscale assemblies as a function of the overall length, the nature of the metal ion, and the distance between metal centers in the PNA scaffold. Other properties of the metal ion, such as coordination and reduction potential, can also affect the electron transfer and these means of control will be explored systematically. Electron transfer is a fundamental chemical process critical to natural processes, such as energy conversion in photosynthesis, and synthetic systems, such as transistors. This work has possible implications for developing molecular-scale electronics and bioelectronics, as well as for establishing the concepts that are of fundamental importance for future advances of this kind. This project is funded through the Collaborative Research in Chemistry Program (CRC) and provides outstanding opportunities for undergraduate, graduate and postdoctoral students to acquire knowledge and skills in supramolecular chemistry, biophysics and computational modeling. The team of researchers also offers outreach programs to interest local students in science.

戴维·H·沃尔德克（David H.该团队将研究包含明确定义位置的顺磁过渡金属离子的PNA的性质。该团队将使用实验（即光谱，显微镜和电化学）和理论（即分子动力学模拟和量子化学方法）来研究这些纳米级组件的电子传输特性，这是整体长度的函数，金属离子的性质，金属离子的性质，以及金属中心之间的距离。金属离子的其他特性（例如协调和还原电位）也会影响电子转移，这些控制手段将被系统地探索。 电子转移是对自然过程至关重要的基本化学过程，例如光合作用中的能量转换和合成系统，例如晶体管。这项工作可能对开发分子规模的电子学和生物电子学以及建立对这种未来进步至关重要的概念。该项目是通过化学计划（CRC）协作资助的，并为本科，研究生和博士后学生提供了出色的机会，以获得超分子化学，生物物理学和计算建模的知识和技能。研究人员团队还提供外展计划，以使当地学生对科学感兴趣。