CAREER: Probing Nucleic Acid Structure through Gas-Phase Ion-Electron Reactions

职业：通过气相离子电子反应探测核酸结构

• 批准号: 0547699
• 负责人: Kristina Hakansson
• 金额: $ 56万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547699&HistoricalAwards=false
• 关键词: CAREER; Probing; Nucleic; Acid; Structure

Professor Kristina Hakansson of the University of Michigan is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to study novel gas-phase ion-electron reactions (electron capture dissociation (ECD) and electron detachment dissociation (EDC)), and to develop tools based on these ionization mechanisms for the mass spectrometric identification of nucleic acids (DNA and RNA). The ultimate goal is to characterize the high order structures of nucleic acids and to map the binding sites in oligonucleotide-drug complexes. The integration of the research activities with diversity programs at the University of Michigan encourages women and underrepresented minorities to embark on scientific careers.The work will add to the fundamental knowledge of gas phase ionization processes, and result in the development of mass spectrometric tools for the identification and characterization of nucleic acids. It will significantly impact crucial areas as diverse as basic biology and the molecular basis of life processes, drug discovery, and forensic science.

Professor Kristina Hakansson of the University of Michigan is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to study novel gas-phase ion-electron reactions (electron capture dissociation (ECD) and electron detachment dissociation (EDC)), and to develop tools based on these ionization mechanisms for the mass spectrometric identification of nucleic acids (DNA and RNA). 最终目标是表征核酸的高阶结构，并绘制寡核苷酸 - 毒物复合物中的结合位点。 密歇根大学的研究活动与多样性计划的融合鼓励妇女和代表性不足的少数群体开始进行科学职业。这项工作将增加对气相电离过程的基本知识，并导致开发质谱工具，以识别和表征核酸的识别和表征。 它将显着影响与基本生物学一样多样化的关键领域，以及生命过程，药物发现和法医学的分子基础。