CAREER:Molecular Origins of Biological Force Generation

职业：生物力产生的分子起源

• 批准号: 0547041
• 负责人: Sean Sun
• 金额: $ 52.41万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547041&HistoricalAwards=false
• 关键词: CAREER; Molecular; Origins; Biological; Force

Sean Sun of Johns Hopkins University is supported by a CAREER award from the Theoretical and Computational Chemistry program for research involving the development of theoretical and computational models of molecular motors, cellular proteins that can generate mechanical force. The project is partially supported by the Cellular Organization program within the Division of Molecular and Cellular Biosciences. The research is developing several coarse-grained elastic models for myosin and dynein, two types of molecular motors involved in movement of muscle, cilia and flagella. In a second phase of the research, elastic models for the collective behavior of ensembles of these molecular motors are being developed. The work is having a broader impact on our understanding of basic biological phenomena. An additional broader impact is through the involvement of students from nearby Morgan State University, a minority-serving institution.

约翰·霍普金斯大学（Johns Hopkins University）的Sean Sun获得了理论和计算化学计划的职业奖项，该计划涉及分子电机的理论和计算模型的开发，分子电机的理论和计算模型，可以产生机械力的细胞蛋白。 该项目在分子和细胞生物科学的分裂内得到了细胞组织计划的部分支持。 该研究正在开发几种肌球蛋白和动力蛋白的粗粒弹性模型，这是两种类型的分子电动机，涉及肌肉，纤毛和鞭毛运动。 在研究的第二阶段中，正在开发这些分子电动机集体集体行为的弹性模型。 这项工作对我们对基本生物学现象的理解产生了更大的影响。 另一个更广泛的影响是通过少数派服务机构的摩根州立大学的学生参与。