SGER: Molecular Origins of Biological Force Generation

SGER：生物力产生的分子起源

• 批准号: 0514749
• 负责人: Sean Sun
• 金额: --
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0514749&HistoricalAwards=false
• 关键词: SGER; Molecular; Origins; Biological; Force

Sean Sun of Johns Hopkins University is supported by a Small Grant for Exploratory Research from the Theoretical and Computational Chemistry program within the Division of Chemistry to begin a project aimed at understanding the molecular origins of biological motor function. Quantitative theories are being developed using methods of non-equilibrium statistical mechanics and the results of this modeling will provide important insights into a number of cellular activities such as motility, mitosis, transcription and gene expression. A coarse-grained approach is being taken and involves a combination of chemical kinetics and elastic theory in combination with atomic-level descriptions. The work has a broad impact on biological science and our understanding of the molecular basis of life processes.

约翰·霍普金斯大学（Johns Hopkins University）的Sean Sun得到了一项小型赠款，用于从化学划分的理论和计算化学计划中进行探索性研究，以开始一个旨在理解生物运动功能的分子起源的项目。使用非平衡统计力学方法开发定量理论，该模型的结果将为许多细胞活动（例如运动，有丝分裂，转录和基因表达）提供重要的见解。正在采用一种粗粒的方法，并涉及化学动力学和弹性理论与原子水平的描述的结合。 这项工作对生物科学和我们对生命过程的分子基础的理解有广泛的影响。