Acquisition of a High-Resolution NMR Spectrometer to Advance Faculty and Undergraduate Research

购买高分辨率核磁共振波谱仪以推进教师和本科生研究

基本信息

批准号：
0521108
负责人：
David Rovnyak
金额：
$ 47.5万
依托单位：
Bucknell University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-01 至 2008-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0521108&HistoricalAwards=false
关键词：
Acquisition Resolution NMR Spectrometer Advance

项目摘要

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Bucknell University will acquire a 500 MHz nuclear magnetic resonance (NMR) Spectrometer. This equipment will enable researchers to carry out studies on a) unusual zinc-binding proteins that will reveal new information on their remarkable structure and activity; b) methodology behind the synthesis of potential ion-channel inhibitors using a class of organorhodium phosphonate species as mechanistic probes; c) the measurement of residual 31P CSA tensors in phospholipid membranes to unambiguously map complex phase behavior; d) characterization of fluid-solid interactions using diffusion experiments to advance on-going studies of multiphase transport; e) use of relaxation and diffusion proton NMR to discover the structural basis for chiral selectivity in capillary electrophoresis separations; and f) the discovery and characterization of natural products with medicinal/biological activities. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research., and this instrument will form the basis for the establishment of a regional, collaborative center for NMR-guided research in central Pennsylvania.

在主要研究仪器 (MRI) 计划的支持下，巴克内尔大学化学系将购买一台 500 MHz 核磁共振 (NMR) 波谱仪。该设备将使研究人员能够对不寻常的锌结合蛋白进行研究，这将揭示有关其非凡结构和活性的新信息； b) 使用一类有机膦酸盐物质作为机械探针合成潜在离子通道抑制剂的方法； c) 测量磷脂膜中残留的 31P CSA 张量，以明确地绘制复杂的相行为； d) 使用扩散实验表征流固相互作用，以推进正在进行的多相传递研究； e) 使用弛豫和扩散质子核磁共振来发现毛细管电泳分离中手性选择性的结构基础； f) 具有药用/生物活性的天然产物的发现和表征。核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要，该仪器将为在宾夕法尼亚州中部建立核磁共振引导研究的区域合作中心奠定基础。