Crosstalk between inflammation, bone destruction and new bone formation in patients with ankylosing spondylitis

强直性脊柱炎患者炎症、骨质破坏和新骨形成之间的串扰

• 批准号: 169556143
• 负责人: Professorin Dr. Uta Syrbe
• 金额: --
• 依托单位: Institut für Muskuloskelettale Medizin
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/169556143?language=en
• 关键词: Crosstalk; between; inflammation; bone; destruction

Inflammation and new bone formation are the hallmarks of the immunopathology observed in ankylosing spondylitis (AS) and determine disease activity, function and longterm outcome. The molecular mechanism of the fluctuating inflammation and its interaction with new bone formation are only poorly understood. In the current project we will apply recent evidence about such an interaction obtained in animal models on the molecular level to histological and immunhistological bone material obtained from AS patients, supplemented by functional in vitro studies. The following question will be addressed: (i) the role of T effector and T regulatory cells in inflammation with special focus on TH17 cells; (ii) interaction between cells and molecules of inflammation and of new bone formation; (iii) investigation of cells/molecules relevant for new bone formation in AS. The results obtained here should enable us to develop better and/or refined current therapies for inhibition of inflammation and osteoproliferaion in AS.

炎症和新骨形成是在强直性脊柱炎（AS）中观察到的免疫病理学的标志，并确定疾病的活性，功能和长期结局。波动炎症的分子机制及其与新骨形成的相互作用仅被了解。在当前的项目中，我们将应用有关分子水平的动物模型中这种相互作用的最新证据，以通过功能性的体外研究补充从AS患者获得的组织学和免疫组织学材料。将解决以下问题：（i）T效应细胞和T调节细胞在炎症中的作用，特别关注Th17细胞； （ii）细胞与炎症和新骨形成的分子之间的相互作用； （iii）研究与新骨形成相关的细胞/分子。此处获得的结果应使我们能够开发出更好和/或精制的当前疗法，以抑制AS中的炎症和骨化剂。