CAREER: Macromolecular Recognition and Differential Ion Channel Functioning

职业：大分子识别和差异离子通道功能

• 批准号: 0447541
• 负责人: Lisa Gentile
• 金额: --
• 依托单位: Western Washington University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-15 至 2007-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0447541&HistoricalAwards=false
• 关键词: CAREER; Macromolecular; Recognition; Differential; Ion

This project describes plans for the continued development of a high quality research program in protein biophysical chemistry, and its integration into an educational plan involving high school, undergraduate, and master's students, as well as high school chemistry and biology teachers. The intellectual merit of this research focuses on understanding the underlying molecular recognition of a class of sulfated steroids that inversely modulate ion channels belonging to the ionotropic glutamate receptor (iGluR) family. Not only will this knowledge further the understanding of molecular recognition, but it will also aid in the ability to decipher the complex functioning of the brain. What function do these neurosteroids play in regulating our memory, cognition, and learning? The educational component integrates high school chemistry and biology teachers along with their students into the above research plan. The specific aims are to:1. Map the binding site of pregnenolone sulfate (PREGS) and pregnanolone sulfate (PREGAS) to the iGluRs and understand why PREGS is a positive regulator of the NMDA receptor, but a negative regulator of the AMPA receptor.2. Involve high school chemistry and biology teachers in an inquiry based investigation, which will enable them to develop new techniques, gather ideas to incorporate into new courses or labs, and satisfy their clock hour requirements.3. Involve high school juniors and seniors in a full time summer research program. This will allow these students to develop critical thinking and problem solving skills, as well as to expose them to the excitement of science and the possibility of future careers in the sciences.The broader impacts of this project are primarily in addressing scientific literacy. Not only will undergraduates and high school students be trained by this program, but also the high school teachers will participate in this program. Involvement of teachers in a research-based inquiry will aid in their ability to teach the process of science to students in a highly effective manner.

该项目介绍了持续开发蛋白质生物物理化学中高质量研究计划的计划，及其整合到涉及高中，本科生和硕士学生以及高中化学和生物学教师的教育计划中。 这项研究的智力优点着重于理解一类硫化类固醇的基本分子识别，这些类固醇的基本识别是反向调节属于离子型谷氨酸受体（Iglur）家族的离子通道。 这些知识不仅会进一步了解分子识别，而且还将有助于破译大脑的复杂功能。 这些神经固醇在调节我们的记忆，认知和学习方面起什么功能？ 教育组成部分将高中化学和生物学教师与学生一起融入了上述研究计划。 具体目的是：1。将硫酸妊娠（PREGS）和硫酸妊娠硫酸盐（Prega）的结合位点映射到iGlurs，并理解为什么PREGS是NMDA受体的阳性调节剂，而是AMPA受体的负调节剂。2。让高中化学和生物学教师参与基于询问的调查，这将使他们能够开发新技术，收集想法以纳入新课程或实验室，并满足其时钟小时的要求3。 让高中大三学生和老年人参加一项全职夏季研究计划。 这将使这些学生能够发展批判性思维和解决问题的技能，并使他们面临科学的兴奋和科学中未来职业的可能性。该项目的更广泛影响主要在于解决科学素养。 该计划不仅会接受本科生和高中生的培训，而且高中教师也将参加该计划。教师参与基于研究的调查将有助于他们以非常有效的方式向学生讲授科学过程的能力。