Core Facility: Morphology - Imaging - Skeletal Characterization

核心设施：形态学-成像-骨骼表征

• 批准号: 169330336
• 负责人: Professor Dr. Michael Amling
• 金额: --
• 依托单位: Institut für Pathologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/169330336?language=en
• 关键词: Core; Facility; Morphology; Imaging; Skeletal

Our group will serve as a core facility for characterization of bone samples of any origin. Our institute is equipped and has ample experince in the characterization of bone samples including imaging modalities (contact-x-ray to μCT-imaging), histology (including undecalcified processing), histomorphometry, bone quality assessment (from BMDD assement by qBEI to μ-xray element analysis) and functional testing (biomechanics). As a core facility we will provide service to both basic and clinical projects. For basic research projects we provide full skeletal characterization of any mouse model used in the program project on highest international standard at the cellular, structural, functional level. For clinical research projects we provide complete processing and evaluation of bone biopsies, including histopathological diagnosis and histomorphometry. Furthermore we will offer μCT imaging not only ex vivo (μCT40) but also in vivo (XtremeCT) at the highest possible resolution. As an integral part of our service we will further teach young scientist working in any project of the program in skeletal imaging and skeletal morphology. To accomplish this task we will establish an annual summer-course ‚Bone Morphology – Imaging – Physiology – Pathology’ open to all young scientist from the program project. Further we would offer to host visiting scientist in our labs in Hamburg for a period of time. This core facility will significantly strengthen the whole program as all partners involved will have full access to the Hamburg experience and infrastructure in bone morphology, imaging and pathology. Thus skeletal analysis of all bone samples within the program project SPP 1468 will meet highest international standards. Furthermore it will be cost effective as this core facility makes it dispensable to establish the expensive and complex infrastructure needed for both bone imaging and undecalcified histological processing of bone for each individual project.

我们的小组将作为表征任何起源的骨样品的核心设施。我们的研究所是等效的，在骨骼样品的表征方面具有丰富的经验，包括成像方式（接触X射线到μCT成像），组织学（包括未被缩放的处理），组织形态计量学，骨质质量评估（从QBEI评估QBEI评估到μ-Xray元素分析）和功能性测试（生物力学）。作为核心设施，我们将为基本和临床项目提供服务。对于基础研究项目，我们提供了在蜂窝，结构，功能层面上最高国际标准的程序项目中使用的任何小鼠模型的完整骨骼表征。对于临床研究项目，我们提供了骨活检（包括组织病理学诊断和组织形态计量学）的完整处理和评估。此外，我们将不仅提供μCT成像，不仅是体内（μCT40），还提供最高分辨率的体内（Xtremect）。作为我们服务不可或缺的一部分，我们将进一步教授年轻的科学家在该计划的任何项目中从事骨骼成像和骨骼形态的工作。为了完成这项任务，我们将建立一个年度的夏季课程，“骨形态 - 成像 - 生理学 - 病理学”对计划项目的所有年轻科学家开放。此外，我们将提供一段时间内在汉堡的实验室接待客座科学家。该核心设施将显着加强整个计划，因为所有涉及的合作伙伴将完全访问汉堡的经验和骨形态，成像和病理学的基础设施。对计划项目SPP 1468中所有骨骼样本的骨骼分析将符合最高国际标准。此外，这将是具有成本效益的，因为该核心设施使建立每个单独项目的骨骼成像和骨骼未钙化的组织学处理所需的昂贵且复杂的基础设施是可赋予的。