Immune Responses to Emerging Ranavirus In Xenopus

非洲爪蟾对新出现的蛙病毒的免疫反应

• 批准号: 0445509
• 负责人: Jacques Robert
• 金额: --
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0445509&HistoricalAwards=false
• 关键词: Immune; Responses; Emerging; Ranavirus; Xenopus

Amphibians are undergoing a world-wide decline; certain species are becoming extinct. It is known that die-offs of some species are associated with certain viral pathogens, but it is not known why their immune systems are not protecting them. If amphibian die-offs partially reflect natural or man-made environmental changes that are immunosuppressive, awareness of these environmental factors are necessary to re-establish ecological balance for the health of man and frogs, alike. This project, uses the frog Xenopus as a laboratory model to investigate the mechanisms of viral immunity and how these organisms mount up their defenses. There are two aims: the first is to define the cellular components of viral immunity in adult frogs; and the second is to determine if the tadpoles are more susceptible due to a generalized immaturity of their immune system. This project will contribute to a better understanding of the causes of amphibian decline, which is of public interest. In addition, it will provide opportunity for minority graduate and undergraduate students to study fundamental immunology in the context of viral diseases, particularly in amphibians.

两栖动物正在全球范围内的下降；某些物种正在灭绝。 众所周知，某些物种的死亡与某些病毒病原体有关，但尚不知道为什么其免疫系统不能保护它们。 如果两栖动物的死亡部分部分反映了免疫抑制的自然或人造环境变化，那么对这些环境因素的认识对于重新建立人类和青蛙健康的生态平衡是必要的。该项目将青蛙爪蟾作为实验室模型来研究病毒免疫的机制以及这些生物如何增强其防御能力。有两个目的：第一个是定义成年青蛙病毒免疫的细胞成分；第二个是确定由于其免疫系统的普遍不成熟而导致的t骨是否更容易受到影响。该项目将有助于更好地理解两栖动物衰落的原因，这是公共利益的。此外，它将为少数族裔毕业生和本科生提供机会，以在病毒疾病（尤其是两栖动物中）研究基本免疫学。