NSEC: Center for Affordable Nanoengineering of Polymer Biomedical Devices (CANPBD)

NSEC：经济实惠的聚合物生物医学设备纳米工程中心 (CANPBD)

• 批准号: 0425626
• 负责人: Ly James Lee
• 金额: $ 257.3万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0425626&HistoricalAwards=false
• 关键词: NSEC; Center; Affordable; Nanoengineering; Polymer

The Nanoscale Science and Engineering Center entitled Center for Affordable Nanoengineering of Polymer Biomedical Devices (CANBD) is a partnership between the U. of Akron, Boston University, UC Berkeley, Johns Hopkins, Florida A&M, and Purdue. The NSEC includes 38 investigators from 9 departments. The Center seeks to develop polymer-based low-cost nanoengineering technology that can be used to produce nanofluidic devices and multifunctional polymer-nanoparticle-biomolecule nanostructures for the next generation medical diagnostic and therapeutic applications. The research plan is comprised of three thrust areas. The Nanomanufacturing Thrust Area combines 'top-down' fabrication and 'bottom-up' molecular self-assembly to produce well-defined passive and active nanostructures. In the Transport Phenomena Thrust Area, the research will achieve design capabilities at the nanoscale by combining nanofluidic design, transport phenomena at the nanoscale, and multiphase transport structures with multiscale modeling and macroscalar property assessment. Biocompatibility issues will be addressed in the Biocompatibility Thrust Area in parallel with the development of new nanofluidic designs and devices. The near-term goal of the three closely linked research thrust areas is to design and fabricate polymer-based, 3D nanofluidic circuits for manipulating the shape, orientation and transport behavior of individual biomolecules in well-defined nanoscale flow fields (5-100 nm). Test bed examples include a simple, handheld protein separation/diagnostic device; a nanoneedle cell patch for low-invasive delivery of genes and macromolecular medicines into cell walls; and biomolecular nanopumps as synthetic ion channels. The ultimate goal is to design and assemble a nanofactory based on the integration of nanofluidic circuits, synthetic chemistry and biological complexation.Center collaborators include at least 20 companies in Ohio and the U.S., Battelle, the Cleveland Clinic Foundation, the National Cancer Institute, Oak Ridge National Laboratory, Wright Patterson Air Force Labs, and researchers in Asia, Australia and Europe. The Center also plans to coordinate closely with NSECs at the University of California at Los Angeles and the University of Illinois-Urbana (nanomanufacturing), the NSF STC at the University of North Carolina at Chapel Hill (environmentally responsible solvents), and the NSF ERCs at the University of Washington (biomaterials and biocompatibility) and the Georgia Institute of Technology (3D tissue models) because of complementary research agendas. The education and outreach vision of the Center is to integrate the latest research developments into a practical student curriculum that imparts multidisciplinary skills and global awareness to both graduate and undergraduate students. The key education elements include a series of new courses to introduce nanoengineering of biomedical devices and related topics; an interdisciplinary curriculum offering an undergraduate minor and a graduate certificate; internships and visits to industry and national laboratories in the U.S. and abroad; and web-based dissemination. The recruitment and retention of minorities and women will be emphasized through close collaboration with minority institutes such as FAMU/FSU. Undergraduate students will participate in research via senior honors theses and targeted REU support. Outreach activities include web-based science modules for K-12 students nationwide; workshops and short courses for high school science teachers and industrial researchers; and on-site research projects and workshops for middle school and high school students supervised by graduate students.

纳米级科学与工程中心题为“负担得起的聚合物生物医学设备（CANBD）的负担得起的纳米工程中心，是阿克伦大学，波士顿大学，加州大学伯克利分校，约翰·霍普金斯，佛罗里达州A＆M和Purdue之间的合作伙伴关系。 NSEC包括来自9个部门的38名调查人员。 该中心旨在开发基于聚合物的低成本纳米工程技术，可用于生产纳米流体设备和多功能聚合物 - 纳米 - 纳米 - 二粒 - 二聚体分子纳米结构，用于下一代医学诊断和治疗应用。 研究计划由三个推力区域组成。 纳米制造推力区域结合了“自上而下”的制造和“自下而上”的分子自组装，以产生定义明确的被动纳米结构。在运输现象推力区域中，该研究将通过结合纳米流体设计，纳米级的传输现象以及具有多尺度建模和宏观属性性能评估的多相传输结构来实现纳米级的设计能力。生物相容性问题将在生物相容性推力区域与新的纳米流体设计和设备的发展并行解决。三个紧密联系的研究推力区域的近期目标是设计和制造基于聚合物的3D纳米流体电路，用于操纵明确定义的纳米级流场（5-100 nm）中单个生物分子的形状，方向和运输行为。测试床的例子包括简单的手持蛋白分离/诊断装置；用于低侵入性基因和大分子药物进入细胞壁的纳米细胞斑块；和生物分子纳米蛋白酶作为合成离子通道。 The ultimate goal is to design and assemble a nanofactory based on the integration of nanofluidic circuits, synthetic chemistry and biological complexation.Center collaborators include at least 20 companies in Ohio and the U.S., Battelle, the Cleveland Clinic Foundation, the National Cancer Institute, Oak Ridge National Laboratory, Wright Patterson Air Force Labs, and researchers in Asia, Australia and Europe.该中心还计划与加利福尼亚大学洛杉矶分校和伊利诺伊州 - 乌尔巴纳大学（纳米制造），北卡罗来纳大学Chapel山分校的NSF STC（Chapel山丘）的NSF STC（环境负责的溶剂）（环境负责）（环境负责的溶剂）（NSF ERC）以及华盛顿大学（Geomatials）的NSF ERC（GEOMATERIALS INTTICE）（GEOROGIAICAID，GEORGIAID），与NSF STC紧密搭配。补充研究议程。该中心的教育和外展愿景是将最新的研究发展纳入实用的学生课程中，该课程赋予研究生和本科生的多学科技能和全球认识。关键的教育元素包括一系列新课程，以引入生物医学设备和相关主题的纳米工程；提供本科生和研究生证书的跨学科课程；美国和国外的工业和国家实验室的实习和访问；和基于网络的传播。通过与FAMU/FSU等少数民族机构的密切合作，将强调少数民族和妇女的招募和保留。本科生将通过高级荣誉论文和有针对性的REU支持参加研究。外展活动包括针对全国K-12学生的基于网络的科学模块；高中科学教师和工业研究人员的讲习班和短课程；以及由研究生监督的中学和高中生的现场研究项目和讲习班。